Noveon IP Holdings Corp.

The B. F. Goodrich Company

William Robert Wilber

Jian-Hwa Guo

Edward S Greenberg

William F Masler, Iii

Carl J Long, Ii

Yona Eckstein

Daniel James Adams

Gary L Julian

David William Weaver

Witoki Szydlowski

The present invention pertains to a method for forming polyacrylic acid granules and granules formed therefrom wherein the granules are flowable, have an increased bulk density relative to the as polymerized polyacrylic acids, and a low amount of dust which is generally characterized herein as particles which pass through a 325 mesh screen. The granules formed by the method of the present invention can be used to prepare controlled release tablets, especially controlled release pharmaceutical tablets. The controlled release properties of the tablets formed from granules prepared according to the present invention are unexpectedly better than tablets prepared from granules formed by other known granulation methods.

Controlled release polyacrylic acid granules and a process for preparing the same

Solid dosage articles such as pharmaceutical tablets for the controlled release of a desired compound such as an active ingredient are directly compressed from a flowable, compressible mixture of the active ingredient, a slightly cross-linked rheology modifying polymer or copolymer, and one or more excipients. The rheology modifying polymer or copolymer is a granulated powder of suitable particle size and is generally made from one or more unsaturated (di)carboxylic acids, half ester thereof, and other optional monomers.

Directly compressed solid dosage articles

A directly-compressed, controlled release tablet contains N-acetyl cysteine as the active ingredient.

Dosage form of N-acetyl cysteine

The present invention provides a blend composition comprising a thermoplastic polyurethane and an acrylic acid copolymer wherein the thermoplastic polyurethane forms the discontinuous phase of the blend. The blend can be used in films or made into fibers for personal care products such as ostomy bags and diapers. Moreover, such materials are also useful for packaging products such as garbage bags.

Degradable blend composition

Reactive multifunctional imide monomers have been discovered from which radiation curable oligomers and polymers may be derived. The reactive imide monomers have at least one functional group which is polymerizable under free radical or ionic polymerization conditions with other similar functional groups. However, the same functional group and reaction product derived therefrom is substantially not subject to cleavage by oxidation or hydrolysis. The reactive imide monomer also contains at least one other functional group which remains intact under the above-described polymerization conditions to form a part of a side chain of the resultant polymer and will cross-link or cure by 2+2 cyclo-addition with other like functional groups upon irradiation.

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Avon Lake, OH, United States of America

William Robert Wilber