Therox, Inc.

Sequent Medical, Inc.

Microvention, Inc.

Covidien LP

Brown University

Tyco Healthcare Group LP

Rhode Island Hospital

Micro Therapeutics, Inc.

Gtech Corporation

William Robert Patterson

Todd J Hewitt

Jeffrey L Creech

Stephen E Myrick

Claudio Plaza

Vincent Divino

Hussain S Rangwala

Brian M Strauss

Brian E Merritt

Hung P Tran

Philippe Marchand

Daniel Welsh

Khoa Vu

Vince Divino

Lawrason Charles Wilbur

Eileen Charlton

Son Pham

Scott Hemmelgarn

Scott William Brennan

Earl Slee

James M Thompson

Mark S Buhr

Stacy Faught

Paul J Zalesky

Ramon Carrillo

Gregory P Watson

Justin Arthur Klotz

Mark Philip Ashby

Jessica Liang

Maria De Jesus Sanson

Ronak Dholakia

Richard Stephen Bein

Richard L Quick

Hans Henkes

Aaron Baldwin

Arto V Nurmikko

Parker Milhous

Thomas McCarthy

J Christopher Flaherty

Hermann Monstadt

Derek J Daw

Joseph Emery

Jeffrey R Morgan

Ming Yin

Darrell Christopher Drysen

Lester Eugene Oestreich

Daw J Derek

Brian Michael Strauss

Khoa Dang Vu

Ramon Torres Carrillo

Ramon Torres Carillo

Tom Wilder

Todd Jeffery Hewitt

Stacy Leon Faught

Anubhav Tripathi

John Philip Donoghue

Harvey F Silverman

Clifton C Dutton

Christopher W Bull

Farah Laiwalla

John Vu

David A Borton

Kenneth J Silverman

Daniel Hoit

Andrew Blakely

John Murphy

Herman Monstadt

Juan Aceros

Earl H Slee

Thomas Mccarthy

Justin Klotz

Earl Howard Slee

Charles Wilbur Lawrason

Todd Jeffrey Hewitt

Maria De Sanson

Christopher Bull

A vascular prosthesis (e.g., stent), and packaging and delivery system to selectively deliver a vascular prosthesis are described. In some embodiments, the vascular prosthesis utilizes a low porosity and high porosity section, and the packaging and delivery system allows the prosthesis to be delivered such that the position of the low porosity and high porosity sections of the prosthesis can vary.

Stent and stent delivery

A system for delivering an implant device to a vascular site in a patient a delivery pusher apparatus, an implant device detachably connected to the delivery pusher apparatus by a tether having a distal end connected to a proximal end of the implant device, wherein the tether is substantially non-tensioned when connecting the implant device to the delivery pusher, and an electrical heating element configured coaxially around at least a portion of the tether, wherein heat generated by the heating element severs the tether at a point near the proximal end of the implant device.

Delivery and detachment systems and methods for vascular implants

Devices and methods for treatment of a patient's vasculature may include a resilient self-expanding permeable implant having a plurality of elongate filaments secured in a hub at a proximal end of the permeable implant. Each of the plurality of elongate filaments may have a diameter between about 0.0005 and about 0.005 inches. The implant includes at least some filaments consisting of nitinol and at least some composite filaments that are drawn filled tube wires comprising an external nitinol tube and a radiopaque material concentrically disposed within the external tube. The implant has at least about 40% composite filaments relative to a total number of filaments, and wherein a total number of filaments is about 10 to about 300.

Filamentary devices for treatment of vascular defects

Described herein are durable coatings, i.e. for medical devices, and methods of forming the coatings.

Durable surface coatings

Devices for treating a cerebral aneurysm may include proximal and distal self-expanding resilient permeable shells each including a plurality of elongate resilient filaments having a braided structure. The distal permeable shell may include a first plurality of filaments gathered at least at the proximal end thereof. The proximal permeable shell may include a second plurality of filaments are gathered at least at the proximal end thereof. The expanded state of the distal permeable shell may have a convex shape at the distal end of the distal permeable shell and the expanded state of the proximal permeable shell may have a generally convex shape at the proximal end of the proximal permeable shell. The expanded states of the distal and proximal permeable shells may also define a toroidal cavity through which an elongate support member extends.

Devices for therapeutic vascular procedures

Devices and methods for treatment of a patient's vasculature are described. The device includes a self-expanding resilient permeable shell having a radially constrained state and an expanded state with a globular, axially shortened configuration. The permeable shell may be a single layer of braided elongate filaments having first and second ends that are secured at the proximal end of the permeable shell. The devices may also include permeable shells made of woven braided mesh having a variable mesh density, i.e., the average size of pores in one region are a different than the average size of pores in another region. Methods of using the device to treat a cerebral aneurysm are also described. Methods of forming a tubular braid are also described. Methods of forming a tubular braid with variable braid densities are described. Methods of forming a tubular braid using a castellated mandrel are also described.

Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a permeable implant having a radially constrained state configured for delivery within a catheter lumen, an expanded state, and a plurality of elongate filaments that are woven together. The permeable implant may include a stiffer proximal portion that is configured to sit at the neck of an aneurysm. The stiffer proximal portion may include coils, stiffening elements, or reinforcement elements disposed about or associated with the filaments or woven together with the filaments.

Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a device that includes a plurality of permeable shells connected by a plurality of coils, each coil connecting at least one pair of permeable shells. The plurality of coils may include an inert hydrogel core that absorbs water.

Devices having multiple permeable shells for treatment of vascular defects

Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a permeable implant connected to an expandable stent through a plurality of wires. The permeable shell is configured for placement in an aneurysm and the expandable stent is configured for placement in a parent vessel proximal, near, or adjacent the aneurysm.

Devices for treatment of vascular defects

Devices and methods for treatment of a patient's vasculature may include a resilient self-expanding permeable implant having a radially constrained elongated state configured for delivery within a catheter lumen and an expanded state with a longitudinally shortened configuration, and a plurality of elongate filaments which are woven together. Each of the plurality of elongate filaments may have a diameter between about 0.0005 and about 0.005 inches. The implant includes at least some filaments consisting of nitinol and at least some composite filaments that are drawn filled tube wires comprising an external nitinol tube and a highly radiopaque material concentrically disposed within the external tube. The implant has at least about 40% composite filaments relative to a total number of filaments, and wherein a total number of filaments is about 10 to about 300.

Methods and devices for treating a cerebral aneurysm utilize a device that includes a self-expanding resilient permeable shell made from elongate resilient filaments. At least some of the filaments have a distal region that extends beyond the distal end of the permeable shell and form an extension having a generally circular shape when expanded. The permeable shell has a radially constrained elongated state configured for delivery within a microcatheter and has an expanded state with a globular, axially shortened configuration. The permeable shell has a plurality of openings formed between the braided filaments. The distal regions of the plurality of filaments that form the extension may be braided, partially braided, or unraveled. Once deployed within the cerebral aneurysm, the extension may be positioned near a dome of the cerebral aneurysm.

Growing community of inventors

Irvine, CA, United States of America

William Robert Patterson