University of Pittsburgh

Ri.med Foundation

Neograft Technologies, Inc.

Cooper Technologies Company

Carnegie Mellon University

The United States Government As Represented by the Department of Veterans Affairs

University of Cincinnati

Universidad De Santiago De Chile

Upmc

William Richard Wagner

Antonio D'Amore

Lorenzo Soletti

Yi Hong

Mohammed S El-Kurdi

Vinay Badhwar

J Christopher Flaherty

David A Vorp

Jianjun Guan

Kazuro Lee Fujimoto

John Joseph Stankus

Young Jae Chun

Yang Zhu

Stephen Francis Badylak

Jon McGrath

Tomo Yoshizumi

Sang-Ho Ye

Eric John Beckman

Alan J Russell

Hongbin Jiang

Xinzhu Gu

Nicholas J Amoroso

Andrew Ziegler

James F Antaki

William J Federspiel

Brian Joseph Frankowski

Bruce A Freeman

David S Schwartzman

Flordeliza Villanueva

Xucai Chen

Jianjun Wang

James L Funderburgh

Jian Wu

Yiqin Du

Richard Garrett Jeffries

Bradley Barth Keller

Fotios M Andreopoulos

Christian Andres Bermudez

Daniel McKeel

Alexander Huber

Sang Ho Ye

Keisuke Takanari

Kimimasa Tobita

Yasumoto Matsumura

Jonathan McGrath

Zuwei Ma

Andrew Fisher

John Mure

Ryan Crouthamel

Vesselin N Shanov

Youngjae Chun

Thomas W Gilbert

Donald O Freytes

Sung Kwon Cho

Yanfei Chen

Catalin Toma

Marco Fazzari

Peter Drew Wearden

Michael Brandt Steketee

Yolandi Van Der Merwe

Christopher R Deible

Seungil Kim

Sachin Shankar Velankar

Luka Pocivavsek

Hong Jiang

Enrique Cerda

Matthew T Wolf

Yingqi Chen

Edith Tzeng

Hideyoshi Sato

Ryotaro Hashizume

Mohammed S El-Kurdl

Joon S Lee

Stephen Emery

Kia M Washington

Stephanie Greene

Antonio DAmore

Murugesan Velayutham

Mohammed S El-kurdi

Jonathan Mcgrath

A method of making a valve structure includes a step of rotating a mandrel and an electrodeposition target attached to the mandrel about a rotational axis of the mandrel. The target includes an exterior surface having at least one conductive surface portion and at least one non-conductive surface portion. The method also includes a step of electrodepositing a polymer matrix of a biodegradable, biocompatible polymer composition onto the at least one conductive surface portion and the at least one non-conductive surface portion of the exterior surface of the rotating electrodeposition target to form the valve structure.

Double component mandrel for electrospun stentless, multi-leaflet valve fabrication

The present invention relates to substrates and composites having dynamic, reversible micron-level luminal surface deformation including texture or geometric instabilities, e.g., surface wrinkling and folding. The surface deformation and its reversal to the original surface form or to another, different surface form, is effective to reduce or prevent surface fouling and, more particularly, in certain applications, to reduce or prevent unwanted platelet adhesion and thrombus formation. The substrates and composites include a wide variety of designs and, more particularly, biomedical-related designs, such as, synthetic vascular graft or patch designs.

Tuning adhesion at contacting device interfaces: geometric tools for minimizing surface fouling

Provided herein is a percutaneous expandable venous cannula device, and related methods. The device is easily inserted, for example, using standard Seldinger technique via the right internal jugular. The device includes multiple, multi-holed limbs that softly fill, e.g., the right atrium to facilitate complete drainage, enable retraction of the chamber in surgery, and mitigate suction occlusion, filling the entire atrium and allowing for efficient and rapid emptying of the chamber. In aspects, the device facilitates minimally-invasive aortic or mitral valve surgery with single placement via the right internal jugular as the sole cannula needed for full support.

Expandable percutaneous cannula

Provided herein is an electrodeposition apparatus for producing long polymeric threads, yarns, or ropes. A method of preparing long polymeric threads, yarns or ropes also is provided.

Processing method and apparatus for micro-structured rope-like material

A zwitterionic polysiloxane polymer (e.g., a polyurethane elastomer) composition having poly(dialkylsiloxane) blocks and a zwitterionic moiety is prepared by the copolymerization of a poly(dialkylsiloxane) diol, a diisocyanate, a tertiary amine alkyl diol, and a poly(dialkylsiloxane) diamine to form a poly(urethane urea) copolymer. A substituted saturated heterocylic compound is reacted with the tertiary amine of the poly(urethane urea) copolymer to introduce a zwitterionic group into the poly(urethane urea) copolymer backbone. A polysiloxane polymer having a zwitterionic moiety is prepared by reacting a diallyl tertiary amine compound and a substituted saturated heterocylic compound to form a diallyl zwitterionic macromer and cross-linking a vinyl terminated poly(dialkylsiloxane) and the diallyl zwitterionic macromer with a curing agent to introduce a zwitterionic group into the poly(dialkylsiloxane) polymer.

Zwitterionic polysiloxane for biomedical devices

Provided are novel biocompatible copolymers, compositions comprising the copolymers, and methods of using the copolymers. The copolymers are non-toxic and typically have an LCST below 37° C. Compositions comprising the copolymers can be used for wound treatment, as a cellular growth matrix or niche and for injection into cardiac tissue to repair and mechanically support damaged tissue. The copolymers comprise numerous ester linkages so that the copolymers are erodible in situ. Degradation products of the copolymers are soluble and non-toxic. The copolymers can be amine-reactive so that they can conjugate with proteins, such as collagen. Active ingredients, such as drugs, can be incorporated into compositions comprising the copolymers.

Biodegradable, thermally responsive injectable hydrogel for treatment of ischemic cardiomyopathy

The invention relates to biomimetic, biodegradable composites including a magnesium (Mg) alloy mesh and a polymer/extracellular matrix (ECM). These hybrid composites, more particularly, are useful for the fabrication of medical implant devices, e.g., scaffolds, and are effective for bone regeneration. The fabrication process includes creating the Mg alloy mesh, and concurrently electrospinning the polymer and electrospraying the ECM onto the mesh.

Mg alloy mesh reinforced polymer/ECM hybrid scaffolds for critical-sized bone defect regeneration

A tubular tissue graft device is provided comprising a tubular member and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.

Bioerodible wraps and uses therefor

An atrioventricular prosthesis device is provided. The device includes a frame at least partially defining and enclosing a central cavity, the frame having a distal portion, a proximal portion, and a middle portion connected therebetween. The device further includes a valve construct formed, at least in part, from a cell growth scaffold, at least partially disposed within the central cavity defined by the frame. The valve construct includes: an annular portion defining an aperture and being connected to the frame for positioning the valve construct within the central cavity of the frame, and a plurality of leaflets extending longitudinally and radially inward from the annular portion. The frame and valve construct are transitionable to a deployed state, in which a diameter of at least a portion of the frame and the valve construct substantially conform to a diameter of a tricuspid and/or mitral valve opening.

Retrievable self-expanding non-thrombogenic low-profile percutaneous atrioventricular valve prosthesis

A system and method are provided for manufacturing filamentous polymer matrices, comprising electrospinning a polymer fiber into a gap between two or more spaced-apart electrodes.

Mandrel-less electrospinning processing method and system, and uses therefor

Provided herein are antioxidant, thermally-responsive copolymer-based compositions and methods of making and using the compositions, e.g., for treatment of ischemia reperfusion injury in a patient. The copolymer comprises a hydrocarbyl backbone, and a plurality of pendant pyrrolidone, antioxidant radical, polyester oligomer, and N-alkyl amide groups.

Biodegradable, antioxidant, thermally responsive injectable hydrogel and uses therefor

A construct comprising a dermal extracellular matrix gel, polymer fibers, and microparticles containing a nitro oleic acid agent.

Nitro-oleic acid controlled release platform to induce regional angiogenesis in abdominal wall repair

Devices for local delivery of tacrolimus or a derivative thereof are provided, wherein the devices comprise a polymeric matrix containing tacrolimus or a derivative thereof that provides for delayed and extended release of tacrolimus or a derivative thereof. The devices can locally deliver tacrolimus or a derivative thereof to injured nervous system tissue upon implantation in a subject. Thus, techniques for local delivery of tacrolimus or a derivative thereof and methods of treatment using such devices are also provided.

Devices and methods for local delivery of tacrolimus

An injectable hydrogel composition that forms a porous gel rapidly after injection fro tissue engineering. The composition comprises a biodegradable, biocompatible, gelling polymer, that is optionally reverse-gelling; an Extra cellular matrix (ECM) material and a biocompatible porogen. Methods of making and using the composition are provided. A kit also is provided comprising the ingredients for making the hydrogel.

Biodegradable, porous, thermally responsive injectable hydrogel as soft tissue defect filler

A template for a valve construct for replacement of at least one of a mitral valve and a tricuspid valve includes at least an anterior leaflet portion and at least a posterior leaflet portion, each leaflet portion having a proximal edge, a distal edge, and side edges extending between the proximal edge and the distal edge. The template further includes a plurality of substantially straight elongated chordae portions each having a proximal end connected to the distal edge of one of the at least two leaflet portions and a distal end extending therefrom and one or more papillary muscle head portions formed at a commissure between distal ends of at least two of the plurality of chordae portions. A total width of the leaflet portions of the template is substantially equal to a circumference of a native annulus of a heart valve.

Stentless biopolymer heart valve replacement capable of living tissue regeneration

Growing community of inventors

Gibsonia, PA, United States of America

William Richard Wagner