Destiny Pharma Limited

Solvias Ag

University of Brighton

William Rhys-Williams

William Guy Love

Derek Brundish

Benoit Pugin

Matteo Santin

Andrew W Lloyd

Xiang Feng

Stephen P Denyer

Xiang Dong Feng

William Love

William G Love

The invention provides the use of a compound of formula (I), or metallated derivative thereof, for killing, inhibiting or preventing the growth of a microbial biofilm: wherein X, X, X, X, Y, Y, Y, Yand Z have meanings given in the description. The biofilm may be on a living or inert support. Preferably, the microorganisms are selected from the group consisting of bacteria and fungi. 

Methods of inhibiting microbial biofilms

A compound of formula I: wherein X, X, X, X, Y, Y, Y, Yand Z have meanings given in the description, and metallated forms of such compounds, which are useful in the treatment of medical conditions for which a photodynamic compound is indicated. Pharmaceutical formulations and methods of treatment of a medical condition for which a photodynamic agent is indicated are also disclosed. Sterilizing solutions comprising a compound of the invention, and the use thereof, are also disclosed.

Porphyrin derivatives and their use in photodynamic therapy

The invention provides the use of a compound of Formula (I), or metallated derivative thereof, in the preparation of a medicament for killing or attenuating the growth of microorganisms by a method which does not comprise exposing the compound to a photodynamic therapy light source or a sonodynamic therapy ultrasound source Formula (I) wherein X, X, X, X, Yi, Y, Y, Yand Z have meanings given in the description. Preferably, the microorganisms are selected from the group consisting off bacteria, mycoplasmas, yeasts, fungi and viruses.

Uses of porphyrin compounds

A prosthesis or implant has a surface carrying a coating comprising at least one phospholipid at a concentration to improve osteointegration. A method of making such a prosthesis or implant and a kit comprising a prosthesis or implant is also described.

Phospholipid-coated implants

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Burgess Hill, United Kingdom

William Rhys-Williams