Lilly Industries, Inc.

Eli Lilly and Company

William R Williamson

John Christopher Saunders

William J Ross

John P Verge

Delme Evans

Compounds of formula I ##STR1## wherein either R.sup.1 and R.sup.2 are both hydrogen or R.sup.1 and R.sup.2, taken together, represent a group of formula (a): ##STR2## in which R.sup.5 is hydrogen, halogen or C.sub.1-4 alkyl, R.sup.3 is hydrogen or a group of formula (b): ##STR3## in which R.sup.6 is hydrogen or C.sub.1-4 alkyl, and R.sup.4 is hydrogen or a group of formula --CHR.sup.7 COOH, where R.sup.7 is hydrogen or C.sub.1-4 alkyl, provided that:

Pharmaceutically active indane derivatives

Acenaphthenes of formula (I) ##STR1## where Ph represents an optionally substituted phenyl group and wherein R.sup.1 represents hydrogen or C.sub.1-4 alkyl are useful anti-inflammatory agents.

Pharmacologically active acenaphthene derivatives

Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 1,2,4-oxadiazole or 1,2,4-thiadiazole nucelus, methods of making the compounds and pharmaceutical formulations containing the compounds. The compounds have anti-allergy activity.

Acylamino derivatives

Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 1,2,4-oxadiazole or 1,2,4-thiadiazole nucleus, methods of making the compounds and pharmaceutical formulations containing the compounds. The compounds having anti-allergy activity.

Acylamino-1,2,4-oxadiazole or thiadiazole derivatives as

Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 1,3,4-oxadiazole or 1,3,4-thiadiazole nucleus, methods of making the compounds and pharmaceutical formulations containing the compounds. The compounds have anti-allergy activity.

Certain acylamino-oxa (or thia) diazoles in treatment of

o-Hydroxybenzophenones and derivatives thereof are described together with a process for their production. The compounds have anti-allergy activity and are characterized by the presence of an alkyl substituent on the hydroxyphenyl ring.

Ketone derivatives

Novel benzophenone derivatives having anti-allergy activity, and pharmaceutical formulations and methods of treatment utilizing benzophenone derivatives.

Benzophenone derivatives

Novel heteroaryl ketone derivatives, specifically a class of phenyl heteroaryl methanone derivatives, having anti-allergy activity, pharmaceutical formulations containing diphenylmethane derivatives and methods of treatment utilizing such derivatives.

Heteroaryl ketone derivatives

An aryl sulphur compound of formula (I) : ##STR1## where R.sup.1 is C.sub.1-4 alkyl; Ar is a phenyl group optionally substituted by halogen or C.sub.1-4 alkyl and wherein Z is S or SO, having antiallergy activity.

Aryl sulphur compounds as antiasthmatics

3-Phenyl substituted 1,2-benzisoxazole acetic and propionic acid derivatives with anti-inflammatory activity.

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Slough, United Kingdom

William R Williamson