Pharmacia & Upjohn Company

Pfizer Corporation

Allergan, Inc.

Pharmacia & Upjohn

Naurex, Inc.

William R Perrault

Bruce Allen Pearlman

Robert C Gadwood

Delara B Godrej

Michael R Barbachyn

Steven Paul Tanis

Danny Thang Dinh

Mark E Schnute

Sajiv Krishnan Nair

Thomas J Fleck

David J Houser

Michele M Cudahy

Dana Scott Toops

Paul Matthew Herrinton

Peter R Manninen

Khalid Diker

Processes for producing diazaspiro lactam compounds and intermediates useful in the processes.

Processes and intermediates for producing diazaspiro lactam compounds

Described herein is a compound having a chemical structure of Formula A: wherein m, p, q, W, Z, Y, X, X, R, R, Rand Rare as defined herein. A diastereo-selective reduction of the compound comprising contacting the compound of Formula A with a reducing agent in an aprotic polar or non-polar solvent is also described.

Enamines and diastereo-selective reduction of enamines

The present invention relates to a one-step process to prepare pharmacologically active 2-oxo-5-oxazolidinylmethylacetamides.

Process to prepare oxazolidinones

Methods of synthesizing pharmacologically useful oxazolidinones are disclosed, and, in particular, a method of manufacturing a 5-(tert-butylcarbamoyl)-aminomethyl-oxazolidinone by condensing a carbamate with a tert-butylcarbamoyl protected derivative of glycidylamine or 3-amino-1-halopropanol.

Oxazolidinone compounds

The invention provides a compound of formula I:wherein G, R, R, and Rhave any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as processes and intermediates useful for preparing such compounds or salts, and methods of treating a herpesvirus infection using such compounds or salts.

4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamide antiviral agents

Methods of producing oxazolidinone compounds

The present invention includes processes for producing 5-hydroxymethyl substituted oxazolidinone alcohols (III) from carbamates (IIA) or a trifluoroacetamide (IIB) using a dihydroxy compound (I) or glycidol (IV) starting material and for the transformation of the hydroxymethyl substituted oxazolidinone alcohols (III) to the corresponding amino compounds, 5-aminomethyl substituted oxazolidinone amines (VII) which are acylated to form commercially useful antibacterial 5-acylamidomethyl substituted oxazolidinone (VIII).

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Kalamazoo, MI, United States of America

William R Perrault