Chiron Corporation

Novartis Vaccines & Diagnostics, Gmbh

William R McCrea

Paul A Renhowe

Cynthia Shafer

Sabina Pecchi

Christopher McBride

Timothy D Machajewski

Elisa Jazan

Clarke Bentley Taylor

Daniel J Poon

Savithri Ramurthy

Keith Bruce Pfister

Allan S Wagman

Paul Andrew Barsanti

Stephen David Harrison

Simon C Ng

Zhi-Jie Ni

Marion Wiesmann

Carla C Heise

Kelly Wayman

Johanna M Jansen

Eliza Jazan

Dirksen Bussiere

Clarke Taylor

Joel B Silver

Joel Benjamin Silver

Teresa Thomas

Organic compounds having the formula I are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.

Quinolinone derivatives

Methods of inhibiting various enzymes and treating various conditions are provided that include administering to a subject a compound of Structure I or IB, a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer. Compounds having the Structure I and IB have the following structures and have the variables described herein. Such compounds may be used to prepare medicaments for use in inhibiting various enzymes and for use in treating conditions mediated by such enzymes. 

Benzimidazole quinolinones and uses thereof

Organic compounds having the structure I are provided where the variables have the values described herein. Pharmaceutical formulations and medicaments include the organic compound or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compound or a pharmaceutically acceptable salt of the organic compound with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation or medicament according to the invention to a patient in need thereof.

Indazole benzimidazole compounds

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Berkeley, CA, United States of America

William R McCrea