Other

W. L. Gore & Associates, Inc.

Gore Enterprise Holdings, Inc.

William R Hardwick

Charles F White

Daniel F Davidson

Robert C Thomson

Alonzo D Cook

Jeanne B Ambruster

Todd V Scantlebury

Stephen E Campbell

Suzanne Motsinger

Charles J Flynn

Robert L Cleek

Mark D Butler

Byron K Hayes

Ulf M E Wikesjo

Shrikant M Mane

There are numerous medical situations involving deficiencies of living bone or periodontal tissue and where increase of living bone or periodontal tissue mass is desired. Methods are described wherein a configured, shell-like device that is capable of being penetrated by living cells and tissues, is implanted into the body of a mammal in such a way as to establish a space, the space being at least partly, bounded by the device. The configuration of the device is such that the configuration of the established space is essentially the same as the configuration of living bone or periodontal tissue that is desired for treatment of the tissue deficiency. At least one protein from the Transforming Growth Factor-Beta Superfamily of proteins is placed within the established space for the purpose of stimulating the growth of living bone or periodontal tissue within the established space. A kit for the generation of living bone or periodontal tissue, comprised of the components mentioned above, is also disclosed.

Methods and articles for regenerating bone or peridontal tissue

There are numerous medical situations involving deficiencies of living tissue and where increase of living tissue mass is desired. Methods are described wherein a configured, shell-like device that is capable of being penetrated by living cells and tissues, is implanted into the body of a mammal in such a way as to establish a space, the space being at least partly, bounded by the device. The configuration of the device is such that the configuration of the established space is essentially the same as the configuration of living tissue that is desired for treatment of the tissue deficiency. At least one tissue stimulating molecular substance is placed within the established space for the purpose of stimulating the growth of desired living tissue within the established space. A kit for the generation of desired living tissue, comprised of the components mentioned above, is also disclosed.

Methods and articles for regenerating living tissue

An implantable bioabsorbable article for the separation and regeneration of tissue at a tissue defect site in the form of a fibrous matrix laminarly affixed to both surfaces of a cell-barrier sheet material. When implanted it allows ingrowth of tissue into the fibrous matrix side of the material; simultaneously the tissue to be regenerated at the tissue defect site is separated from the ingrowing tissue by the cell-barrier sheet material. A method for making the implantable bioabsorbable article is also described.

Implantable bioabsorbable article

A method for treatment of periodontal disease is disclosed. The gingival tissue is separated from the tooth surface in an area where periodontal disease is present. A biocompatible, porous material such as expanded polytetrafluoroethylene capable of supporting ingrowth of gingival connective tissue and preventing apical migration of gingival epithelium is placed in a laminar relationship to a portion of the perimenter of the tooth surface. The gingival tissue is repositioned around the tooth and in contact with the porous material, with the porous material positioned between the gingival tissue and the tooth. Articles for the treatment of periodontal disease are also disclosed. One article comprises a first portion which is capable of supporting ingrowth of gingival connective tissue and preventing apical migration of gingival epithelium and a second portion which is impermeable to oral tissues and bacteria. Articles and methods for the treatment of bone defects are also disclosed. The articles have a first portion with a surface capable of supporting connective tissue ingrowth configured to contact the bone surrounding the defect and a second portion with a surface substantially impermeable to tissue ingrowth and bacteria invasion extending from the first portion to cover the defect.

Methods and articles for treating periodontal disease and bone defects

A method for treatment of periodontal disease is disclosed. The gingival tissue is separated from the tooth surface in an area where periodontal disease is present. A biocompatible, porous material such as expanded polytetrafluoroethylene capable of supporting ingrowth of gingival connective tissue and preventing apical migration of gingival epithelium is placed in a laminar relationship to a portion of the perimeter of the tooth surface. The gingival tissue is repositioned around the tooth and in contact with the porous material, with the porous material positioned between the gingival tissue and the tooth. Articles for the treatment of periodontal disease are also disclosed. One article comprises a first portion which is capable of supporting ingrowth of gingival connective tissue and preventing apical migration of gingival epithelium and a second portion which is impermeable to oral tissues and bacteria.

Growing community of inventors

Flagstaff, AZ, United States of America

William R Hardwick