University of Florida Research Foundation, Incorporated

Specialty Coating Systems, Inc.

University of Pennsylvania

Other

Union Carbide Chemicals & Plastics Technology Corporation

Arkema Inc.

William R Dolbier, Jr

An-Rong Li

Cameron J Koch

Alexander V Kachur

Xiao X Rong

Brian R James

Kirsten A Skov

Sydney M Evans

Chyng-Yann Shiue

Ian R Baird

Maher Y Elsheikh

Lotfi Hedhli

Rakesh Kumar

Walter E Stalzer

Samia Aït-Mohand

Valerie Rodriguez-Garcia

Tatiana Sergeeva

Kai Wu

Naoto Takechi

Oleksandr S Kanishchev

Zhaoyun Zheng

Alex J Roche

Jian-Xin Duan

Jianxin Duan

M A Asghar

He-Qi Pan

Puhui Xie

Buvaneswari Gopal

Provided herein are pentafluorosulfanyl (SF) mefloquine derivatives, formulations, methods of making the SFderivatives, and uses thereof.

2-pentafluorosulfanyl (SFS) mefloquine derivatives, formulations, methods of making, and uses thereof

The subject invention pertains to pentafluorosulfonyl (SF5) substituted pyrroles, thiophenes, 3-pyrrolines and 2,5-dihydrothiophenes, as well as methods for their synthesis.

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A composition comprising perfluoro-[2,2]-paracyclophane dimer compound is disclosed. The synthesis reaction of the paracyclophane dimer from 1,4-bis(chlorodifluoromethane)-2,3,5,6-tetrafluorobenzene involves heating in the presence of a metal catalyst and a solvent. A perfluorinated paraxylylene coating formed from the perfluorinated paracyclophane dimer is also disclosed.

Perfluoroparacyclophane and methods of synthesis and use thereof

A process for producing a class of polyarylenes having p-bis-(chlorodifluoromethyl) benzene or p-bis(bromodifluoromethyl) benzene as a comonomer. The p-bis-(chlorodifluoromethyl) benzene or the p-bis(bromodifluoromethyl)benzene act as precursors in a polycondensation reaction with a difunctional monomer.

Methods for producing thermoplastic fluoropolymers

NovelF-fluorine compounds useful for non-invasive imaging techniques such as PET, for detecting tissue hypoxia and methods for preparing them are disclosed. Novel intermediate compounds and methods for preparing them are also disclosed. Diagnostic kits useful in practicing the methods of claimed invention are also provided.

Preparation of compounds useful for the detection of hypoxia

NovelF-flourine compounds useful for non-invasive imaging techniques such as PET, for detecting tissue hypoxia, and methods for preparing them are disclosed. Novel intermediate compounds and methods for preparing them are also disclosed. Diagnostic kits useful in practicing the methods of claimed invention are also provided.

The subject invention provides methods of fluorinating an aromatic or chloroaromatic compound comprising combining an aromatic compound, a chloroaromatic compound, a mixture of aromatic compounds, a mixture of chloroaromatic compounds, or a mixture of chloroaromatic and aromatic compounds and a fluorinating composition comprising at least one active fluorinating agent selected from the group consisting of CuF, AgF, HgF, TeF, MnF, FeF, and CoFand at least one support selected from the group consisting of activated carbon, ZnF, CaF, MgF, AlF, and combinations of activated carbon, ZnF, CaF, MgF, or AlF.

Oxidative fluorination of aromatic and chloroaromatic derivatives

The subject invention provides convenient, regiospecific and highly stereoselective addition of SFCl in high yield to a variety of alkenes and alkynes.

Method for incorporation of pentafluorosulfanyl (SF5) substituents into aliphatic and aromatic compounds

Nitroaromatic compounds and immunogenic conjugates comprising a novel nitroaromatic compound and a carrier protein are disclosed. The invention further presents monoclonal antibodies highly specific for the claimed nitroaromatic compounds, the compounds' protein conjugates, the compounds' reductive byproducts, and adducts formed between the compounds and mammalian hypoxic cell tissue proteins. The invention is further directed to methods for detecting tissue hypoxia using immunohistological techniques, non-invasive nuclear medicinal methods, or nuclear magnetic resonance. Diagnostic kits useful in practicing the methods of claimed invention are also provided.

Detection of hypoxia

The subject invention relates to a process for the trifluoromethylation of sulfates, including cyclic and acyclic sulfates. The subject invention further pertains to the compounds produced by the trifluoromethylation of sulfates.

Process for trifluoromethylation of sulfates

Processes for the preparation of parylene dimers, and more particularly to processes for the preparation of derivatives of octafluoro-&lsqb;2,2&rsqb;paracylophane, otherwise known as AF4.

Process for the preparation of derivatives of octafluoro-&lsqb;2,2&rsqb; paracylophane

A method of making TFPX using an S,2 type nucleophilic displacement reaction. The method includes reacting a nucleophilic fluorine molecule with a nonfluorinated-tetrahalo-p-xylene molecule. Exemplary nucleophilic fluorine molecules include, but are not limited to, CsF, KF, NaF and LiF. The nonfluorinated-tetrahalo-p-xylene molecules may include, &agr;,&agr;,&agr;&prime;,&agr;&prime;-tetrachloro-p-xylene, &agr;,&agr;,&agr;&prime;,&agr;&prime;-tetrabromo-p-xylene or &agr;,&agr;,&agr;&prime;,&agr;&prime;-tetraiodo-p-xylene. The reaction may be carried out in an open or closed container. Furthermore, the reaction may be carried out in the presence of a phase transfer catalyst. In certain embodiments, the reaction is carried in a substantially solvent-free environment.

TFPX synthesis

Nitroaromatic compounds for the detection of hypoxia

A method for the synthesis of TFPX-dichloride is disclosed. The method involves reacting hexachloro-p-xylene with anhydrous HF in an inert organic solvent. The reaction is advantageous in that it produces relatively high yields of TFPX-dichloride, provides little waste, and is carried out as a simple, one-step process.

Process for preparation of TFPX-dichloride

A process for the preparation of octafluoro-�2,2!paracyclophane includes contacting a reactant selected from the group consisting of 1,4-bis(bromodifluoromethyl)benzene (dibromide), 1,4-bis(chlorodifluoromethyl)benzene (dichloride), and 1,4-bis(iododifluoromethyl)benzene (diiodide) with trimethylsilyltributyltin (TMSTBT) (a reducing agent) and fluoride ions in a refluxing solution of hexamethylphosphoramide (HMPA) or dimethylsulfoxide (DMSO) in tetrahydrofuran (THF) at conditions effective to promote a reaction product comprising octafluoro-�2,2!paracyclophane.

Growing community of inventors

Gainesville, FL, United States of America

William R Dolbier, Jr