American Cyanamid Company

Basf Aktiengesellschaft

University of Virginia Patent Foundation

William R Baumbach

Bruce Christian Black

Bosco S Wang

John S Logan

Ian C Hart

Michael P Beluch

Homayoun Sadeghi

Richard Allen Houghten

Kevin R Lynch

Michael Oliver Thorner

Bruce D Gaylinn

John R Zysk

Jeffrey K Harrison

The present invention provides a method to control parasitic and saprophagous mites on beneficial insects such as honeybees via the application of a parasiticidally or saprophagouscidally effective amount of a mitochondrial electron transport inhibitor or a pyrimidine compound of formula I.

Parasitic and saprophagous mite control in beneficial insects

The present invention provides a method to control parasitic mites on beneficial insects, such as honeybees, via the application of a parasiticidally effective amount of tebufenpyrad.

Parasitic mite control on beneficial insects

The present invention provides peptides having pure somatostatin antagonist activity. Also provided are methods for increasing the release of growth hormone, insulin, glucagon and gastric enzymes in mammals and a method for the enhancement of immune function and growth in mammals.

Peptides useful as somatostatin antagonists

The present invention is directed to antibodies, in particular monoclonal antibodies, which specifically bind to somatotropin binding proteins of animals, but not with the corresponding somatotropin receptors. The antibodies may be used alone to enhance the growth of animals, or may be used together with somatotropin to potentiate the effect of somatotropin in animals. The antibodies may also be used to assay the level of somatotropin binding protein of animals.

Antibodies specifically recognizing somatotropin binding proteins

Growth hormone releasing hormone (GHRH) receptor binding has been characterized using a unique binding assay utilizing iodinated GHRH probes. Photoaffinity GHRH probes have been constructed which allow for photolabeling and characterization of the receptor. In addition, high affinity biotinylated GHRH analogs have been constructed. Solubilization of GHRH-R/GHRH complexes and extraction of specifically bound GHRH using a mild detergent solution, followed by affinity chromotography, leads to a substantially purified GHRH-R isolate. Electrophoretic treatment of the GHRH-R isolate produces GHRH-R of sufficient purity to conduct sequencing of the receptor. Cloning of a gene encoding for polypeptides (protein or fragments thereof) having GHRH-R activity is accomplished using a bacterial host, and the cloned gene is expressed in a mammalian cell line.

Nucleic acid molecule encoding the porcine growth hormone receptor

The present invention is directed to antibodies, in particular monoclonal antibodies, which specifically bind to somatotropin binding proteins of animals, but not with the corresponding somatotropin receptors. The antibodies may also be used to assay the level of somatotropin binding protein of animals.

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Hopewell, NJ, United States of America

William R Baumbach