University of Pennsylvania

Other

New York University

William R Abrams

Haim H Bau

Michael G Mauk

Daniel Malamud

Changchun Liu

Eran Geva

Harvey M Friedman

Earl Jim Bergey

Xianbo Qiu

Lee Richard Denman

Xianbo Ceiu

Thandavarayan Nagashunmugam

John Spruance

Daneil Malamud

Provided are devices adapted to isolate, amplify, and detect nucleic acids that may be present in a biological sample. The devices can, in some embodiments, isolate, amplify, and detect nucleic acid in a single chamber. In other embodiments, the devices are adapted to isolate and amplify nucleic acids in a reaction chamber, after which the nucleic acids may be communicated to a pervious medium&#x2014;such as a lateral flow strip&#x2014;where the user may label and detect the nucleic acids.

Isothermal nucleic acid amplification reactor with integrated solid state membrane

Disclosed are integrated devices capable of performing a polymerase chain reaction within a single vessel. Also disclosed are related methods of sample analysis.

Integrated PCR reactor for cell lysis, nucleic acid isolation and purification, and nucleic acid amplication related applications

The invention includes compositions comprising substantially purified salivary glycoproteins and carbohydrate ligands thereof which are useful in methods for the treatment and prevention of HIV-1 infection. The invention also includes methods for the treatment and prevention of HIV-1 infection comprising contacting a composition of the invention with a human patient. Additionally, the invention includes antibodies and kits useful in the treatment and prevention of HIV-1 infection.

Compositions and methods useful in treatment and prevention of HIV-1 infection

A method for sonic analyzation on-line and in real time or off-line in post processing of a topographic representation of a seafloor to provide the latitude and longitude of an object producing a corresponding anomaly appearance identified in a topographic respresentation generated from a side scan sonar tow fish includes in the on-line, real time analyzation the steps of sequentially touching the tip of a sonic digitizer stylus to a point on the line representation of the seafloor laterally opposite the appearance of the anomaly; to the leading edge and the trailing edge of the anomaly and to the tip of an acoustic shadow of the anomaly appearance; and, if length is desired, to the top and bottom edges of the anomaly appearance. A computer includes a set of instructions to calculate the desired information and is coupled to a host computer associated with a vessel which tows the sonar tow fish along a course covering an area of interest of the seafloor. The computer receives the position, speed and heading of the tow fish at each point contacted by the stylus tip and calculates the latitude and longitude, height, length and width of the corresponding object. In the off-line post processing mode the stylus tip is touched to a calibration point prior to the anomaly analysis and to a fix mark immediately before and after an identified anomaly and inputting the latitude and longitude associated with the respective fix marks. The remaining steps in the post processing mode are similar to the on-line, real time analysis.

Method for sonic analysis of an anomaly in a seafloor topographic

The forward movement of a pipe-laying vessel when laying pipe offshore is controlled to maintain the position of the pipe as laid on the sea bed as close as possible to the desired track. The position of the touch down point on the sea bed of the pipeline suspended from the vessel is measured at periodic intervals by driving a survey vessel fitted with an echo location device along the already laid line. The measured position of a touch down point is compared with the desired track and any deviation is computed. Further movements of the pipe-laying vessel are adapted to minimize this deviation.

Offshore pipe laying

Growing community of inventors

Merion, PA, United States of America

William R Abrams