The University of North Carolina at Chapel Hill

Southern Research Institute

William Perry Janzen

Paul Alexander Dayton

Chatura Nadisha Jayakody

Jason Eric Streeter

Cameron Champion Wood

Siddharth Kaup Shenoy

Samantha Gail Pattenden

Joseph A Maddry

Rudolph L Juliano

Bing Yang

Xin Ming

Canhong Cao

Methods and systems for using encapsulated microbubbles to process biological samples are disclosed. According to one aspect, a method for using encapsulated microbubbles to process a biological sample includes creating a mixture comprising encapsulated microbubbles mixed with a biological sample and adding activation energy to the mixture to cause at least some of the microbubbles to oscillate or burst and thereby process the sample, including effecting cell lysis, shearing DNA, and/or performing tissue dispersion.

Methods and systems for using encapsulated microbubbles to process biological samples

Methods of administering an oligonucleotide of interest into a cell in vitro or in vivo are described. In the methods, a small organic compound active agent is concurrently administered to the cell in an amount effective to increase the delivery of the oligonucleotide into the cell, and/or increase the activity of said oligonucleotide in the cell. Compositions useful for carrying out the method are also described.

Small molecules that enhance the activity of oligonucleotides

Growing community of inventors

Chapel Hill, NC, United States of America

William Perry Janzen