Minimed, Inc.

Medtronic Minimed, Inc.

Zyomed Corp.

Laxmi Therapeutic Devices, Inc.

Other

Capricor Therapeutics, Inc.

University of California

Minimed Technologies, Ltd.

Metronic Minimed, Inc.

William P Van Antwerp

John Joseph Mastrototaro

Poonam S Gulati

Nannette M Van Antwerp

Rajiv Shah

Timothy Lewis Ruchti

Sandeep Gulati

John L Smith

Rebecca K Gottlieb

Peter C Lord

Paul S Cheney, Ii

Bradley J Enegren

Sheldon B Moberg

Thomas Arnold Peyser

Joe H Satcher, Jr

Bahar Reghabi

Stephen M Lane

Gary Cohen

George W Patterson

James D Holker

Nannette M Schnabel

Christian C Decker

Joel Goldsmith

Pam S Roller

Sanford Widran

James R Daugherty

Michael E Miller

Cary D Talbot

Guillermo A Calle

Shaun M Pendo

David J Vachon

Glenn Noronha

James Jordan Rosenberg

Michael I Larkin

Paul Citron

Kevin Branch

Christopher B Darrow

Eric A Grovender

Susan M McConnell

Joseph C Walsh

Eunjoo Jin

Aaron M Heiss

Sheana Karre

Adrian Prokop

Sara Akiko Stinson

Jason Fong

John J Mastrototoro

Jennifer Harder

Matthew Yavorsky

Thomas Metzmaker

Yunbing Wang

Udo Hoss

Jeffery Van Funderburk

Alfred E Mann

Colin A Chong

Jenn-Hann Larry Wang

Sarnath Chattaraj

Keith A Oberg

Peter Carl Lord

Garry M Steil

Paul H Kovelman

Susan McConnell

Richard E Purvis

John J Shin

Darren Y K Yap

Kerstin Rebrin

Eugene Levin

Deborah C McIntyre

Gerald E Adomian

Leanne Beer

Brooks B Cochran

Philip J Hudak

Todd M Gross

Elango S Minnoor

Bill C Ponder

Eric P Geismar

Jonathan Reilly

Andrew J L Walsh

Li Yao

Hsiao Lieu

Seonyoung Kim

Lian Luo

Paul V Goode, Jr

Dianne L Judd

Norman Dy

Daron Evans

Todd Kinsfather

Raymond D Clark

Magdi F Habib

Isabella Camille Darke

Jason Goldberg

Reghu Kunnath Rajan

Sarah Clabeaux

Dallin Ostler

Roshanne Malekmadani

Scott Mallett

Ashley Nicole Farnkopf

Paul Mounce

Andreas H R Pfuetzner

Xiao Zhu

A monitor for determining analyte concentrations in vivo, includes a housing configured to adhere to the skin of a subject, an elongate sensor body configured to extend from the housing into the skin of the subject, an analyte sensing region positioned on the sensor body such that the analyte sensing region is configured to be held in the dermis of the skin of the subject, and at least one engagement surface configured to facilitate increased anchoring of the sensor body in the skin of the subject.

Dermal sensor for determining analyte concentrations

An applicator assembly for applying at least a portion of an analyte monitor includes a frame having a longitudinal axis and an opening, a resilient member having at least a first portion fixed relative to the frame and a second portion movable axially relative to the frame, a needle, and a cap engageable with the frame to cover at least part of the opening. The cap is adjustable to increase a bias on the resilient member and to move the second portion of the resilient member away from the opening. When the cap is separated from the frame, the second portion of the resilient member is configured to be held relative to the frame. The hold on the second portion of the resilient member is releasable, such that the bias on the resilient member advances the second portion of the resilient member and the needle towards the opening.

Applicators for glucose monitors, methods for applying glucose monitors, and glucose monitors for use with such applicators

A system and method for personalized calibration for glucose sensing. In some embodiments, the method includes obtaining a plurality of first glucose measurements from a subject, at a plurality of first sampling times during a time interval, using a first glucose sensor; obtaining a plurality of second glucose measurements from the subject, at a plurality of second sampling times during the time interval, using a second glucose sensor; and estimating a first in-vivo calibration parameter for the first glucose sensor and the second glucose sensor, based on the first glucose measurements and the second glucose measurements, wherein a first in-vivo time-constant, relating blood glucose to an output of the first glucose sensor, is different from a second in-vivo time-constant, relating blood glucose to an output of the second glucose sensor.

Personalized calibration for glucose sensing

A method for forming an enzymatic biosensor includes preparing a first deposition solution comprising an enzyme, placing a substrate in the first deposition solution, applying an electrical potential to a working electrode of the substrate to deposit the enzyme on the working electrode, placing the substrate in a second deposition solution comprising electro-polymerizable monomers, and passing a current through the working electrode to polymerize the monomers to form an electropolymerized polymer layer over the enzyme deposited on the working electrode.

Electrochemical method for enzyme immobilization on biosensor electrodes

Systems and processes for managing data relating to one or more medical or biological conditions of a plurality of subjects (such as patients) over a wide area network, such as the Internet, may be employed for diabetes subjects or subjects with other medical conditions requiring monitoring and/or treatment over time. Such systems and processes provide various functions for several types of users, including patients or subject-users, healthcare provider-users and payor entity-users and combinations thereof, which allow for improved treatment and medical data management of individual subjects and groups of subjects and which allow collection and analysis of aggregate data from many subject sources, for improving overall healthcare practices of providers and subjects (e.g., patients).

Medical data management system and process

Therapeutic compositions containing chimeric natriuretic peptides for treating chronic kidney disease alone, heart failure alone, or chronic kidney disease with concomitant heart failure are described. The therapeutic compositions have enhanced stability characteristics to facilitate storage and delivery by provisioning apparatuses under conditions of elevated temperature and mechanical stress. Methods for increasing the stability of therapeutic compositions containing chimeric natriuretic peptides are further described.

Chimeric natriuretic peptide compositions and methods of preparation

In a noninvasive system for detection/measurement of analytes in tissue, spectra from the medium are deconstructed into features. Conditioned features, which contain frequency components specific to the analytes, are derived from one or more features after modulating a carrier kernel with the feature. The conditioned features are computationally collided with one or more Zyotons that are co-dependent with the conditioned features. One or more collisions amplify the energy absorbed by the analyte from radiation directed to the tissue. The value of the amplified energy is transformed into an accurate estimate of the concentration of the analyte. Depending on the analyte type, a particular tissue region is targeted and/or one or more parameters of the computational collision are selected.

Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing

A collision-computing system detects and amplifies the energy associated with a feature signal to determine occurrences or absence of events, such as ultrasonic and/or geophysical events, or to determine presence and/or concentrations of substances such as blood glucose, toxic chemicals, etc., in a noisy, high-clutter environment or sample. To this end, a conditioned feature, obtained by modulating a carrier kernel with a feature signal, is collided with a Zyoton&#x2014;a waveform that without a collision can travel substantially unperturbed in a propagation medium over a specified distance. The conditioned feature and the Zyoton are particularly constructed to be co-dependent in terms of their respective dispersion velocities and the divergence of a waveform resulting from the collision. The collision operation can transfer at least a portion of the feature energy to the resulting waveform, and the transferred energy can be amplified in successive collisions for detecting/measuring events/substances.

Systems and methods for collision computing for detection and noninvasive  measurement of blood glucose and other substances and events

A synthetic projection system determines analyte concentration, such as blood glucose concentration, from a spectral-energy change associated with an uncharacterized instance of a medium in which the analyte is likely present. The projection system is factory calibrated for different instances of the medium, without needing instance-specific training or calibration. The projection system includes a set of projector curves, each relating spectral-energy change values obtained by analyzing reference medium samples to analyte concentrations in those samples. Each projector curve also corresponds to a respective range of energy-change gradients, determined using a group of surrogate media characterized according to analyte concentrations measured using a reference system. A spectral-energy-change gradient for the uncharacterized medium may be computed to select one of the projectors curves. Analyte concentration in the uncharacterized medium can be reliably computed at a specified high level of accuracy using the spectral-energy change associated therewith and the selected curve.

Systems and methods for generating and using projector curve sets for universal calibration for noninvasive blood glucose and other measurements

In a noninvasive system for detection/measurement of glucose and other analytes in a medium such as tissue, illumination is directed to the medium and corresponding radiation from the medium is collected. Spectral energy changes associated with fragment(s)/feature(s) obtained from the collected radiation are determined using collision computing. Such spectral energy changes generally represent analyte concentration. The illumination is controlled to target a particular volume of the medium and/or such that the spectral energy changes become directionally monotonic with respect to analyte concentration. The illumination parameters include: intensity, wavelength, bandwidth, focal length, and/or duration of illumination, location and/or a size of an illuminated spot on the medium surface, depth at which the illumination can reach below the medium surface, spacing between the illuminated spot and a spot on the medium surface from which radiation is collected, and angle of the illumination relative to the medium surface.

Systems and methods for blood glucose and other analyte detection and measurement using collision computing

In a noninvasive system for detection/measurement of glucose and other analytes in a medium such as tissue, illumination is directed to the medium and corresponding radiation from the medium is collected. Spectral energy changes associated with fragment(s)/feature(s) obtained from the collected radiation are determined using collision computing. Such spectral energy changes generally represent analyte concentration. The collection of radiation and/or illumination is controlled either to target a particular volume of the medium or such that the spectral energy changes become directionally monotonic with respect to analyte concentration, or both. The collection parameters include: duration of collection, location and/or a size of a collection spot on the medium surface, and angle of a collector relative to the medium surface. The illuminated and/or collection spots may be treated to improve accuracy of analyte measurement.

Systems and methods for control of illumination or radiation collection for blood glucose and other analyte detection and measurement using collision computing

In a noninvasive system for detection/measurement of glucose and other analytes in a medium such as tissue, spectra from the medium are deconstructed into features. Conditioned features, which contain frequency components specific to glucose or the other analytes, are derived from one or more features by modulating a carrier kernel with the feature. The conditioned features are computationally collided with one or more Zyotons that are co-dependent with the conditioned features. One or more collisions amplify a property of the analyte e.g., energy absorbed by glucose in tissue from radiation directed to the skin. A gradient of several values of the amplified property, each value corresponding to a particular radiation pattern according to a spectroscopic tomographic sequence, is used to select a suitable projector curve, with which a representative amplified value is projected to an accurate estimate of the concentration of glucose or the other analytes, without needing personalized calibration.

Systems and methods for noninvasive blood glucose and other analyte detection and measurement using collision computing

Methods of treating heart failure, or decreasing blood pressure, comprising administering an NP at an appropriate dose, or in an amount sufficient to provide particular concentrations of NP, are provided.

Methods of treatment of heart failure with natriuretic peptides

Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes a hydrophilic comb-copolymer having a central chain and a plurality of side chains coupled to the central chain, wherein at least one side chain comprises a silicone moiety.

Analyte sensors and methods for making and using them

An apparatus for sensing multiple parameters includes an implantable housing and a plurality of implantable sensors disposed within the implantable housing. The plurality of implantable sensors sense parameters in a patient, such as biological or physiological parameters, for example, and each responds to an analyte in the patient. The plurality of implantable sensors may include, but is not limited to, electrochemical, potentiometric, current and optical sensors.

Implantable apparatus for sensing multiple parameters

Growing community of inventors

Valencia, CA, United States of America

William P Van Antwerp