Vanderbilt University

William P Tansey

Shaun R Stauffer

Stephen W Fesik

Edward T Olejniczak

Jason Phan

Feng Wang

Alex Gregory Waterson

James M Salovich

Rocco D Gogliotti

Changho Han

Joseph R Alvarado

KyuOk Jeon

Jonathan D Macdonald

Selena Chacon Simon

Sameer S Nikhar

Alexey Kuznetsov

Substituted N-phenyl sulfonamide compounds inhibit WDR5-MYC interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation.

WDR5-MYC inhibitors

Described are N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)benzamide and acetamide-containing compounds that inhibit WDR5 and associated protein-protein interactions, pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating disorders and conditions in a subject.

WDR5 inhibitors and modulators

Described are compounds that disrupt the WDR5-MLL1 protein-protein interaction, pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating disorders and conditions in a subject.

Growing community of inventors

Brentwood, TN, United States of America

William P Tansey