Applied Research Systems Ars Holding N.v.

Biogen Idec Ma Inc.

Nsgene A/s

William P Sisk

Holly Prentice

Philip Kusk

David Rogers Buckler

Jens Tornøe

Shirley Vui Cheng

Mette Grønborg

Holly Lynn Prentice

Lars Ulrik Wahlberg

The extracellular domain, or fragment thereof, of a gonadotropin glycoprotein hormone receptor is expressed and secreted in a soluble and functionally hormone-binding form. A recombinant baculovirus transfer vector is constructed to include a gene segment encoding the extracellular domain, or fragment thereof, of the glycoprotein hormone receptor joined in frame with a gene segment encoding a baculovirus signal peptide and operably linked to a baculovirus promoter. Recombinant baculovirus generated by transfection or co-transfection of insect cells are then used to infect insect host cells for the expression and secretion of soluble receptor.

Method of expressing and secreting soluble extracellular domains of

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Boxborough, MA, United States of America

William P Sisk