Biocryst Pharmaceuticals, Inc.

Island Pharmaceuticals Ltd.

William P Sheridan

Yarlagadda Sudhakara Babu

Pravin L Kotian

Shanta Bantia

Amanda Mathis

Yarlagadda S Babu

Provided are compounds of the formula I and pharmaceutically acceptable salts, solvates, and hydrates thereof, for use in treating or suppressing a SARS-CoV-2 infection in a subject. A novel dosing regimen for administration of the disclosed compounds is also provided comprising administering at least one loading dose and at least one maintenance dose of the disclosed compound. The compounds of the disclosure are characterized, in part, by favorable pharmacokinetics for the active pharmaceutical ingredient, particularly in conjunction with the dosing regimen described.

Methods, compositions, and dosing regimens for treatment of SARS-CoV-2 infections

Disclosed are novel compounds comprising an imino-ribose derivative covalently linked to a carbocycle or heterocycle. Pharmaceutical compositions comprising the compounds of the invention are also described. Methods of inhibition, treatment and/or suppression of viral infections with the compounds of the invention are also described. The compositions or methods may optionally comprise one or more additional anti-viral agents.

Anti-influenza compositions and methods

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Durham, NC, United States of America

William P Sheridan