Molecular Design International, Inc.

Other

Debiopharm S.a.

William P Purcell

Harlie A Parish, Jr

Andrew Purcell

Richard D Gilliom

A self-controlling watering system, comprising a water reservoir having a first end, a second end, and an internal compartment of a predetermined volume, a first cover designed to secured to the first end of the tank, a second cover designed to secured to the second end of the tank, wherein the second cover has a first opening, and a second opening, a pump secured to the first cover within the internal compartment of the water reservoir, compartment designed to securely fit within the first opening of the second cover, wherein a third end of the compartment is open and a fourth end of the compartment is closed, a controller positioned within the compartment and for controlling the pump to initiate watering cycles according to a preselected program regarding the frequency of watering and quantity of water.

Self watering planter assembly

The invention provides a topical formulation adapted for treatment of a skin condition comprising (i) at least one retinoid; and (ii) salicylic acid or an ester, amide, salt, or solvate thereof. The invention also includes a kit for treatment of skin conditions comprising a retinoid and salicylic acid, as well as a method of treating skin conditions utilizing the inventive formulation and kit.

Topical compositions for treatment of skin conditions

Esters and amides of 9-cis-retinoic acid are synthesized, formulated into pharmaceutically acceptable carriers and administered for the treatment of acne vulgaris, cystic acne, hyper-pigmentation, hypo-pigmentation, psoriasis, dermal and epidermal hypoplasia and kerotoses, the reduction of wrinkling of the skin as an incident of aging and actinic damage, normalization of the production of sebum, the reduction of enlarged pores, promoting the rate of wound healing, limiting of scar tissue formation during healing and the like. They are additionally useful for treatment or amelioration of the same additional classes of skin disorders as is retinoic acid itself and other retinoids. These disorders include ichthyoses (e.g., ichthyosis hystrix, epidermolytic hyperkeratosis, and lamellar ichthyosis), follicular disorders (e.g., pseudofolliculites, senile comedones, nevus comidonicas, and trichostatis spinulosa), benign epithelial tumors (e.g., flat warts, trichoepithelioma, and molluscum contagiosum), perforated dematoses (e.g., elastosis perforans seripiginosa and Kyrles disease), and disorders of keratinization (e.g., Dariers disease, keratoderma, hyperkeratosis plantaris, pityriasis rubra pilaris, lichen planus acanthosis nigricans, and psoriasis). The esters and amides of 9-cis-retinoic acid are also effective for the non-irritating treatment of effects attributable to aging and particularly to photodamage and photoaging. The use of these compounds extends to non-irritating treatments involving the retardation and reversal of additional dermal and cosmetic conditions which are ameliorated by tretinoin such as the effacement of wrinkles, improvement in appearance, namely color and condition of the skin, spots caused from exposure to the sun as well as other skin disorders. The esters and amides of 9-cis-retinoic acid are exceptionally active when compared to other retinoids employed for such indications, and are also exceptionally safe in effective therapeutic doses in contrast to other retinoids.

9-cis retinoic acid esters and amides and uses thereof

The dermal use of non-irritating retinoids such as the esters and amides of 13-cis and 13-trans-retinoic acid for effecting the reduction and reversal of photoaging and skin cancer is disclosed.

Dermal uses of trans-retinoids for the treatment of photoaging

Dermal uses of cis-retinoids for the treatment of cancer

Dermal uses of trans-retinoids for the treatment of cancer

Esters and amides of 13-trans-retinoic acid are disclosed which are used for the treatment of acne and skin diseases.

Topical transretinoids for treatment of acne and skin diseases

Esters and amides of 13-cis-retinoic acid are disclosed which are used for the treatment of acne and skin diseases.

Topical prodrugs for treatment of acne and skin diseases

Derivatives of pyridopyrimidinone of the following formulae: ##STR1## wherein Y is C.dbd.S, C.dbd.O, SO.sub.2, or CH.sub.2 ;

Pyridopyrimidinone derivatives

Novel therapeutically active derivatives of benzamide, having the general formula ##STR1## in which R.sub.1 and R.sub.2, independently of each other, are hydrogen or a lower alkyl group, R.sub.3 is a phenyl or lower alkyl or lower alkenyl group, R.sub.4 is a halogen or a trifluoromethyl or nitro-group, R.sub.5 is a sulphamoyl or carboxyl or carboxy-alkyl group, and the potassium salts of these derivatives. These compounds are diuretics and hypotensors (blood pressure depressants) and they lower the angiotensin and renin functions, with prolonged action.

Growing community of inventors

Memphis, TN, United States of America

William P Purcell