Nelson Research & Development Company

William O McClure

A method for assaying prostaglandins of the E and F series comprising the sequential steps of reducing the keto groups in a sample containing the prostaglandins to hydroxy groups, selectively oxidizing the prostaglandin 15-OH groups to keto groups, reducing the keto groups to hydroxy groups by means of a radioactive labeled chemical reducing agent, isolating radioactive labeled prostaglandins and measuring the amount of radioactivity of the isolated radioactive labeled prostaglandins.

Method for assay of prostaglandins

A method for assaying prostaglandins of the E series by reacting a compound of this series with NaB.sup.3 H.sub.4, isolating the tritiated prostaglandin and measuring its radioactivity.

Method of assay for prostaglandins of the E series

A method for assaying prostaglandins of the F.sub..alpha. series by reacting a compound of this series with a compound having the formula R--B(OH).sub.2 wherein R is a radical containing a fluorescent or radioactive label, isolating the reaction product and measuring the amount of fluorescence or radioactivity of the reaction product.

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So. Pasadena, CA, United States of America

William O McClure