Epivax, Inc.

Faac, Inc.

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Biotest Ag

Rhode Island Council on Postsecondary Education

Food and Drug Administration

William Martin

Anne Searls De Groot

Daniel S Rivera

Travis Staley

David S Bouwkamp

Steven Olson

Christopher Hegarty

Chuck Deakins

James R Mason

Stuart Ball

Philip C Duczyminski

Joseph Lewis Clift

Nikolaos Dimitri Zachary Kazakos

Dale Eammon Atkin

Amy S Rosenberg

Stephen Owen Gregory

Steven Olsen

Annie De Groot

Jens Daufenbach

Phyllis Losikoff

Anne DeGroot

Karina Winterling

Christopher Ungerer

Steffen Kistner

Dan Rivera

A driving simulation system includes a simulated driver cockpit which includes simulated controls, a display control input, and a video display providing a simulated driving environment to the driver. The system further includes a computerized simulation control module including programming to operate a driving simulation. The driving simulation includes driving rules. The module further including programming to monitor performance of the driver during the driving simulation and compare the performance of the driver to the driving rules. The module further includes programming to generate an untextualized feedback regarding performance of the driver relative to the driving rules, monitor an input by the driver to the display control input, and selectively display the untextualized feedback to the driver based upon the input by the driver to the display control input. The selective display is operable to enable private viewing of the untextualized feedback by the driver.

Driving simulation scoring system

The present is directed to compositions comprising regulatory T cell epitopes, wherein said epitopes comprise a polypeptide comprising at least a portion of SEQ NOS: 1-14, fragments and/or variants thereof, as well as methods of producing and using the same.

Regulatory T cell epitopes

The present invention relates to the field of therapeutic proteins, in particular, to recombinant coagulation factors. It provides a recombinant Factor VIII (FVIII) protein comprising specific point mutations at defined positions, which serve to reduce the immunogenicity of said FVIII protein, wherein the Factor VIII protein substantially retains its coagulant activity. It further provides nucleic acids encoding said de-immunized protein, cell lines and methods of recombinant preparation as well as pharmaceutical compositions comprising the recombinant FVIII of the invention, which are advantageous for use in treatment of patients with Hemophilia A, particularly those who have not yet been treated with a FVIII product. Additionally, it can be a safe alternative for previously treated patients and even for patients who have developed an immune-response to FVIII, e.g., for immune-tolerance-induction therapy (ITI/ITT) or rescue ITI. The invention also provides an assay for determining immunogenicity of a protein.

De-immunized factor VIII molecule and pharmaceutical compositions comprising the same

A pump panel training device is provided and includes a plurality of simulated gages operable to imitate gages upon a fire truck pump panel, a plurality of simulated controls operable to imitate controls upon the fire truck pump panel, and a simulated water hose operable to imitate one of water temperature changes, water temperature pressure, and water hose vibration for the fire truck pump panel.

Pump operation panel simulator

The invention is directed to T cell epitopes wherein said epitopes comprises a peptide or polypeptide chain comprising at least a portion of an immunoglobulin constant or variable region. The invention also relates to methods of using and methods of making the epitopes of the invention.

Regulatory T cell epitopes, compositions and uses thereof

The present is directed to compositions comprising regulatory T cell epitopes, wherein said epitopes comprises a polypeptide comprising at least a portion of SEQ NOS: 1-124 (and/or fragments and variants thereof), and optionally 1 to 12 additional amino acids distributed in any ratio on the N-terminus and/or C-terminus of the polypeptide of SEQ ID NOS: 1-124, as well as methods of producing and using the same.

A driving simulation system is configured to train a driver. The system includes a simulated driver cockpit which includes a steering wheel and at least one video display providing a simulated driving environment to the driver. The system further includes a computerized simulation control module including programming configured to operate a driving simulation through the simulated driver cockpit. The driving simulation includes driving rules. The programming is further configured to monitor performance of the driver during the driving simulation, compare the performance of the driver to the driving rules, and while the driving simulation is still in operation, provide untextualized feedback to the driver regarding performance of the driver.

A driving simulation system is configured to train a driver. The system includes a simulated driver cockpit which includes a steering wheel and at least one video display providing a simulated driving environment to the driver. The system further includes a computerized simulation control module including programming configured to operate a driving simulation through the simulated driver cockpit. The driving simulation includes combined driving rules including generic driving rules configured to universal driving standards and local standard operating procedures for a particular locale. The programming further monitors performance of the driver during the driving simulation, compares the performance of the driver to the combined driving rules, and provide feedback to the driver.

Growing community of inventors

Cumberland, RI, United States of America

William Martin