Sanofi

Sanofi-a Ventis Deutschland Gmbh

William Marsh

Matthew Meredith Jones

Anthony Paul Morris

Joseph Butler

Samuel Steel

Richard James Vincent Avery

Robert F Veasey

David Aubrey Plumptre

Christian Rehbein

Simon Lewis Bilton

Michael Cameron Bainton

Daniel David Higgins

A sensor device removably attachable to a drug delivery device includes a sensing arrangement arranged within the sensor device and circuitry configured to process signals provided by the sensing arrangement. The sensing arrangement is configured such that, when the sensor device is attached to the drug delivery device, the sensing arrangement is operable to read encoded information present on a rotatable component internal to the drug delivery device and that is able to be sensed through a window or aperture of the drug delivery device, and is operable to sense through the window or aperture at least a part of a drive mechanism of the drug delivery device. The circuitry is configured to determine information relating to a set dose, and to determine information relating to whether the drug delivery device is in a dose setting mode or whether the device is in a dose delivery mode.

Sensor device removably attachable to a drug delivery device

The present disclosure is directed to a spring arrangement for use in a drug delivery device and a drug delivery device including such a spring arrangement. The spring arrangement includes a clutch spring which is located axially interposed between a stationary housing component and an axially movable sleeve. The sleeve includes clutch features adapted to engage corresponding clutch features of a clutch element. The clutch spring biases the clutch features and the corresponding clutch features into engagement. The sleeve is coupled to a button such that upon actuation of the button the sleeve is translated against the bias of the clutch spring from a proximal position in which the sleeve is rotationally locked to the housing component into a distal position in which the sleeve is rotationally un-locked from the housing component. Upon release of the button the clutch spring translates the sleeve and the button into the proximal position.

Spring arrangement and drug delivery device herewith

The present disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing and at least two separate component parts, wherein for example at least one of these component parts performs a movement relative to the housing during dose setting and for example at least one of these component parts performs a movement relative to the housing during dose dispensing, and wherein the relative movement of the at least two separate component parts with respect to each other during dose setting differs from the relative movement of the at least two separate component parts with respect to each other during dose dispensing. The device further comprises a monitoring device, wherein at least one component part of the device is diaphanous to allow optical detection of the movements of the at least two separate component parts relative to the housing, relative to the monitoring device and/or relative to each other during dose setting and/or during dose dispensing by the monitoring device.

Drug delivery device

A drive mechanism () for a drug delivery device comprising&#x2014;a piston rod (), &#x2014;a trigger member () coupled with the piston rod () in such a manner that rotational movement between the piston rod () and the trigger member () is constrained in a first state, the trigger member () being elastically deformable in such a manner that the piston rod () is rotationally moveable with respect to the trigger member () in a second state, &#x2014;a trigger button () being suitable for activating the deformation of the trigger member ().

Drive mechanism for a drug delivery device

The disclosure refers to a handheld injection device comprising a housing, a dose indicator positioned within and axially constrained to the housing and rotatable with respect to the housing during dose setting and during dose dispensing, a gauge element, which is at least partly interposed between the housing and the dose indicator, wherein the gauge element is axially guided within the housing and in threaded engagement with the dose indicator such that rotation of the dose indicator causes an axial displacement of the gauge element (). A contrast element having a first marking is provided and at least a region of the gauge element is provided with a second marking, with the first marking and/or the second marking being visible through a first window or aperture in the housing depending on the axial position of the gauge element within the housing.

Injection device

The present disclosure is directed to a drive sleeve with a hollow body having a ring of crown teeth with a first outer diameter forming a clutch interface at a first end and a thread extending on an outer surface of the body. The thread has a major diameter and a minor diameter, wherein the ring of crown teeth has at least two cavities. The at least two cavities extend on the outer surface of the body from the first end to the thread and defining a second outer diameter which is smaller than the major diameter of the thread. Further, some embodiments are directed to a drug delivery device with such a drive sleeve and a method for assembling a drug delivery device.

Drive sleeve, drug delivery device and method for assembling a drug delivery device

A sensor device removably attachable to a drug delivery device includes a sensing arrangement arranged within the sensor device and

A drive mechanism () for use in a drug delivery device () is provided. The drive mechanism () comprises a housing () with a proximal and a distal end and a piston rod () which is rotatable with respect to the housing (). The drive mechanism () further comprises a nut member () which is selectively rotationally lockable with respect to the housing (), wherein the drive mechanism () is switchable between a setting mode of operation and a dispensing mode of operation. The drive mechanism () is configured such that in the setting mode of operation, the nut member () and the piston rod () are rotatable with respect to the housing (), and in the dispensing mode of operation, the piston rod () is rotatable with respect to the housing () and the nut member () is rotationally locked with respect to the housing (), wherein, when the piston rod () rotates, the piston rod () moves distally with respect to the nut member ().

A method for assembling a drive spring, especially into a drug delivery device includes rotating a component part to which the drive spring is attached in a first direction, followed by a rotation of the component part in the opposite direction and followed by attachment of a rotational stop. Further, the disclosure includes a drug delivery device for selecting and dispensing a number of user variable doses of a medicament, which device comprises a pre-charged drive spring.

Method for assembling a drive spring and drug delivery device with a spring

The present disclosure relates to a drive mechanism which is suitable for an injection device, especially a pen type drug delivery device and to such a drug delivery device. The mechanism comprises a spring driven rotatable drive member, a rotatable driven member, a clutch rotationally coupling the driven member and the drive member in a coupled state and allowing relative clockwise and anti-clockwise rotation between the driven member and the drive member in a decoupled state, and a spring biasing the clutch into its coupled state and allowing relative axial movement between the drive member and the driven member into the decoupled state of the clutch against the bias of the spring. The clutch comprises a first ring of crown teeth on the drive member and a second ring of corresponding crown teeth on the driven member with each crown tooth having in the clockwise and the anti-clockwise direction different ramped tooth angles such that the teeth are allowed to override each other in the de-coupled state of the clutch with a different resistance in the clockwise and the anti-clockwise direction.

Drive mechanism and drug delivery device herewith

A drug delivery device for selecting and dispensing a number of user variable doses of a medicament includes a housing having a tubular portion with an inner thread, a piston rod having a threaded portion and a distal end, and a bearing having a distal face and a proximal face. The bearing includes a retaining stem protruding from the proximal face. The piston rod includes a distal portion having an outer diameter which is smaller than the inner diameter of the inner thread of the tubular portion and comprising at its distal end at least one retaining clip engaging the retaining stem. The axial length of the tubular portion is smaller than or equal to the axial distance between the proximal face of the bearing disc and the distal end of the threaded portion of the piston rod. During manufacturing of the device, the retaining clip engages the retaining stem prior to the inner thread of the tubular portion engages with the threaded portion of the piston rod.

Drug delivery device with threaded housing and piston, and method for manufacturing the same

The present invention is generally directed to an injection device for selecting and dispensing a number of user variable doses of a medicament. The injection device comprises a housing () having a longitudinal axis (I), a dose setting member () rotatable relative to the housing () during dose setting, a drive member () which is rotationally constrained to the housing () in a first dose setting mode and which is rotatable relative to the housing () in a second dose dispensing mode, a locking element () which is permanently rotationally constrained to the housing () and movable relative to the housing () in a direction parallel to the longitudinal axis (I) between a first dose setting position and a second dose dispensing position, an actuation button () movable relative to the housing () in a direction parallel to the longitudinal axis (I) between a first dose setting position and a second dose dispensing position for switching the injection device between the first dose setting mode and the second dose dispensing mode, a ratchet () for transmitting torque from the dose setting member () to the drive member () during dose dispensing and allowing relative rotational movement between the dose setting member () and the drive member () during dose setting, the ratchet () comprising first ratchet features () rotationally constrained to the driver () and second ratchet features () rotationally constrained to the dose setting member (), and a spring (). The spring () biases the locking element () and the actuation button () into their first dose setting position and biases the first ratchet features () into engagement with the second ratchet features ().

Injection device with compression spring for engaging ratchet elements, for biasing an actuation button, and for biasing a locking element into a dose setting mode

The mechanism includes a body defining an axial direction, a dial that is moved for setting a dose, an indicator member coupled with the dial, and a movable window displaying a surface area of the indicator member. The indicator member is axially moved relative to the body.

Mechanism for a drug delivery device and drug delivery device comprising the mechanism

The present disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament comprising a clicker arrangement. The device comprises a housing (), a dose selector () operable to set a dose by rotation relative to the housing (), a number sleeve () coupled to the dose selector () and arranged within the housing () such that at least a portion of the number sleeve () is visible through a first aperture () in the housing (), a piston rod () coupled to the housing () and to a drive sleeve () such that rotation of the drive sleeve () relative to the housing () causes the piston rod () to translate relative to the housing (), a clutch () arranged between the number sleeve () and the drive sleeve (), and a dispense clicker comprising a flexible arm () and a toothed profile (). The device further comprises a button () operable to effect dose dispensing. The clutch comprises a separate clutch element () which is permanently rotationally constrained to the number sleeve (). The flexible arm () is provided on the clutch element () and the toothed profile () is provided on the button ().

Growing community of inventors

Buckinghamshire, United Kingdom

William Marsh