Massachusetts Institute of Technology

The Brigham and Women's Hospital, Inc.

Tasc, Inc.

William M Wells, Iii

Tomas Lozano-Perez

W Eric Grimson

Gil J Ettinger

Steven J White

Ronald Kikinis

Ron Kikinis

An image data registration system and method of storing a first data set of three-dimensional image data associated with a predetermined portion of an object with reference to a first coordinate frame; obtaining and storing a second data set of three-dimensional image data associated with a surface of the predetermined portion of the object with reference to a second coordinate frame; obtaining and storing a third data set of three-dimensional image data associated with a probe in the vicinity of the predetermined portion of the object with reference to a third coordinate frame; and registering the first, second and third data sets to generate a matched image data set in which the first, second and third coordinate frames are relatively aligned with one another.

System and method of registration of three-dimensional data sets

A statistical method for correcting for intensity inhomogeneities in the images produced by magnetic resonance imaging equipment. The method uses knowledge of tissue properties and gain inhomogeneities to correct the gain artifact, thereby improving intensity-based segmentation of the volume spanned by the imagery into the various tissue types that are present. The method utilizes the Expectation-Maximization algorithm to simultaneously estimate tissue class and the radiofrequency gain field. The algorithm iterates two components to convergence: tissue classification and gain field estimation. The method combines them in an iterative scheme that yields a powerful technique for estimating tissue class and radiofrequency gain.

Correction of magnetic resonance imager intensity inhomogeneities using

The present invention provides an image data registration system and method of storing a first data set of three-dimensional image data associated with a predetermined portion of an object with reference to a first coordinate frame; obtaining and storing a second data set of three-dimensional image data associated with a surface of the predetermined portion of the object with reference to a second coordinate frame; and registering the first data set and the second data set to generate a matched image data set in which the first coordinate frame is aligned with the second coordinate frame. In an alternative embodiment, the present invention provides a method of registering three-dimensional data sets, comprising generating a first data set of image data with reference to a first coordinate frame; generating a second data set of image data with reference to a second coordinate frame; selecting a predetermined subset of data points from the first data set; matching the subset of data points to all possible corresponding subsets of data points associated with the second data set and producing a set of hypothesized transformation data sets; and sequentially mapping said second data set to each of the hypothesized transformation data sets to form a solution data set, the solution data set representative of a highly accurate transformation of the second data into the first coordinate frame associated with the first data set.

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Cambridge, MA, United States of America

William M Wells, Iii