Cynvenio Biosystems, Inc.

Zhuhai Sanmed Biotech Ltd

William M Strauss

Behrad Vahidi

Xin Ye

Dongwen Li

Mike Trejo

Robert Justice Shartle

Systems and methods for handling a variety of sample and preparatory fluids in a rack specifically configured for compatibility with predetermined liquid handlers such as automated pipettors or multi-channel manual pipettors and set up for magnetic based sample preparation. The rack can hold all of the necessary sample and reagent vials, and present them to the pipettor in some embodiments in a way that allows for parallel operation. The rack includes slidable magnets that in some embodiments are actuatable directly by the pipettor, eliminating a layer of complexity. Combined with a suitable pipettor the magnet enabled rack supports a multistep magnetic based sample preparation capability in a high throughput manner at one station that enhances sample purity throughout magnetic separation processes.

System and processes for isolation and enrichment by magnetic separation

Provided are devices for recovery of cells from a microfluidic device. In particular, provided are open-ended conical tubes for recovery of cells from a microfluidic device and methods of use. In some embodiments, the open-ended conical tubes comprise: i) a nipple portion (), wherein the nipple portion () comprises a length in the range of 0.2 to 0.3 inches, a diameter in the range of 0.2 to 0.3 inches, wherein the nipple portion () comprises a narrow orifice;

Open-ended conical tube for recovering cells from a microfludic chip

Provided are stimulus-sensitive microparticles and their use, e.g., in tracking the efficiency of recovery of a rare cell population (e.g., circulating tumor cells) from a mixture of cells; and in supplying control nucleic acids to index a molecular assay independent of the rare cell selection steps.

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Westlake Village, CA, United States of America

William M Strauss