American Cyanamid Company

Merck + Co., Inc.

William M Maiese

Donald B Borders

Raymond T Testa

David P Labeda

Joseph J Goodman

May D Lee

Guy T Carter

Michael Greenstein

Jane P Kirby

Taikwang M Lee

Richard G Wax

Amedeo A Fantini

Jerald S Feitelson

Plasmid DNA was isolated from two Actinomadura species and characterized by mapping the sites of restriction endonuclease cleavages and by calculation of total molecular size.

Plasmids derived from actinomadura species

This invention provides a method for treating chronic respiratory disease, fowl cholera and necrotic enteritis in infected birds, by orally administering thereto a pharmaceutically effective amount of antibiotic LL-E19020.alpha., antibiotic LL-E19020.beta. or a physiologically acceptable salt thereof.

Method for controlling chronic respiratory disease, fowl cholera and

A new antibacterial agent designated LL-C19004 is described, which antibacterial agent is produced through microbiological fermentation, under controlled conditions using a new species of Saccharothrix, Saccharothrix espanaensis (NRRL 15764).

Antibiotic LL-C19004

The invention is a process for the production by fermentation of the antibacterial and antiparasitic agents designated LL-D42067.alpha., to methods for its recovery and concentration from crude solutions and to processes for its purification. The invention includes within its scope the biologically pure culture of the antibiotic.

Culture and process for producing antibiotic LL-D42067alpha

This invention relates to antibiotic LL-E19020.alpha. and LL-E19020.beta. derived from the microorganism Streptomyces lydicus subspecies tanzanius NRRL 18036, which are useful as an antibacterial agent.

Antibiotic LL-E19020 .alpha. and .beta.

Antitumor agents LL-D49194.alpha..sub.1, LL-D49194.beta..sub.1, LL-D49194.beta..sub.2, LL-D49194.beta..sub.3, LL-D49194.gamma., LL-D49194.delta., LL-D49194.epsilon., LL-D49194.xi., LL-D49194.eta., LL-D49194.omega., LL-D49194.omega..sub.2 and LL-D49194.omega..sub.3.

Antitumor agents LL-D49194.alpha..sub.1, LL-D49194.beta..sub.1,

Antibiotic LL-D42067.alpha. derived by aerobic fermentation of the microorganism Actinomadura madurae subspecies simaoensis NRRL 15734, useful as an antibacterial and antiparasitic agent.

Antibiotic LL-D42067.alpha.

An antibiotic, designated FR-02A or efrotomycin, is obtained by culturing Streptomyces lactamdurans in a fermentation broth and extracting the whole broth with a water immiscible polar organic solvent to obtain the antibiotic FR-02A.

Production of antibiotic FR-02A (efrotomycin) by streptomyces

This invention relates to a new antibiotic agent which also possesses growth promoting activity. The antibiotic is isolated from the fermentation broth of Streptomyces lactamdurans by solvent extraction and designated Efrotomycin.

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Bridgewater, NJ, United States of America

William M Maiese