California Institute of Technology

William M Clemons, Jr

Thomas F Miller, Iii

Axel Mueller

Michiel Niesen

Bin Zhang

Stephen Marshall

Sarah Reisman

Roger Nani

Sergiy Levin

Shyam M Saladi

Kyoung-Soon Jang

Membrane protein expression can be predicted using statistical frameworks to provide an enhanced subset of sequences, out of an initial larger set of potentially expressing sequences, by using features derived from sequences and a model parameterized through a dataset of known expression levels. Also, membrane protein experimentation protocols can be designed using the statistical frameworks in concert known outcomes to identify which laboratory conditions are most likely to produce successful results.

Methods and systems for predicting membrane protein expression based on sequence-level information

Methods and systems are described to provide computerized trajectory-based methods to represent translocon-associated protein trajectories, provide proteins or protein sequences with desired translocon-associated biogenesis features, screening proteins or protein sequences to provide proteins or protein sequences with desired translocon-associated biogenesis features, screening translocon-associated biogenesis feature determinants to provide proteins or protein sequences with desired translocon-associated biogenesis features, identifying translocon-associated biogenesis feature determinants of a given protein sequence, computer-based protein sequence identification methods, computer-based methods for identifying correlations in a set of protein sequences, computer-based methods for identifying correlations between experimental data and computer-generated data in a protein sequence, and computer-based methods for determining which modifications of a protein sequence do not substantially affect a translocon-associated biogenesis feature of the protein sequence.

Translocon-associated biogenesis features and related methods, systems and products

A cysteine hydrazide nicotinamide (Cyhn) reagent designed for the enrichment of bacterial glycoproteins is provided. Methods for purification of free oligosaccharides and their analysis are also provided.

Cysteine hydrazide nicotinamide for glycomics and glycoproteomics uses

Growing community of inventors

Pasadena, CA, United States of America

William M Clemons, Jr