University of Michigan

William Lloyd

Mary-Ann Mycek

James M Scheiman

Leng-Chun Chen

Euisik Yoon

Stephen E Feinberg

Diane M Simeone

Cynthia Marcelo

Barbara McKenna

Malavika Chandra

Robert H Wilson

Oliver Lee

Fan Wu

Jeremy Taylor

Seung Yup Lee

Shiuhyang Kuo

Hyungjin Myra Kim

A system for analyzing tissue includes a platform and an optical sensing unit coupled to the platform. The optical sensing unit has a detector and a plurality of light sources surrounding and electrically isolated from the detector. The optical sensing units obtain optical data for tissue analysis.

System for analyzing tissue

This disclosure provides a method of determining the viability of at least one cell via quantification of nicotinamide adenine dinucleotide (phosphate) (NAD(P)H), flavin adenine dinucleotide (FAD), and/or collagen. The method includes the steps of contacting the at least one cell with light having a wavelength of from 700 to 900 nm, using two photon excitation, or from 335 to 400 nm, using one photon excitation, to induce an optical response from the NAD(P)H, FAD, and/or collagen and measuring the optical response. The method also includes the step of quantifying one or more of an amount, spatial localization, and/or time-dependent response of the NAD(P)H, FAD, and/or collagen utilizing the optical response.

Method of determining the viability of at least one cell

Multimodal optical spectroscopy systems and methods produce a spectroscopic event to obtain spectroscopic response data from biological tissue, either ex vivo or in vivo, and compare the response data with a model configured to correlate the measured response data and the most probable attributes of the tissue, thus facilitating classification of the tissue based on those attributes.

Multimodal spectroscopic systems and methods for classifying biological tissue

Growing community of inventors

Wixom, MI, United States of America

William Lloyd