Wisconsin Alumni Research Foundation

University of Michigan

Depuy Synthes Products, Inc.

Tyco Electronics Corporation

Trs Holdings LLC

Other

Warsaw Orthopedic, Inc.

Kansas State University Research Foundation

Worcester Polytechnic Institute

Tissue Regeneration Systems, Inc.

Dearing, Matthew T.

Spalding, Gabriel C.

William Leo Murphy

Leenaporn Jongpaiboonkit

Scott J Hollister

Michael P Schwartz

David J Mooney

Ben Kim Graf

Mark D Markel

Stephen E Feinberg

James R Adox

Xiaohua Yu

James A Thomson

Jeffery Walter Mason

Zhonggang Hou

Francesco Migneco

Jae Sung Lee

Ngoc Nhi Le

Padma Gopalan

Igor I Slukvin

Wayne Stewart Alden, Iii

Jue Zhang

Martin C Peters

Siyoung Choi

David H Kohn

Samantha Kelly Schmitt

Nicholas E Propson

Andrew Salim Khalil

Frank LaMarca

Chia-Ying Lin

Gene Ichiro Uenishi

Yan Lu

Hunter J Johnson

Eric Huy Dang Nguyen

Matthew Brian Parlato

William T Daly

Stefan Zorn

David Belair

Elizabeth Anne Aisenbrey

Elizabeth Emma Torr

Frank Lamarca

Brian Henri Otrando

Stephen J Orphanos

Ray Vanderby

Robert G Dennis

Glenn R Gaudette

Marsha W Rolle

Michael W Toepke

Steven Reppucci

Justin Koepsel

Gabriel Cooper Spalding

Connie Sue Chamberlain

Luis Fabircio Medina-Bolivar

Joshua Gershlak

Anna Clements

Cheryl M Soref

Gianluca Fontana

Carol Cramer

Tanja Dominko

Sarah Hernandez

Pam Weathers

Bernard Binder

Andrew Khalil

Connie Chamberlain

Angela Xie

Gene I Uenishi

Hamisha Ardalani

Charles D Page

Ngoc Nhi Thi Le

Nicholas Impellitteri

Angela W Xie

Gaurav Kaushik

Matthew Zanotelli

James A Molenda

Geoffrey Baer

Wayne Stewart Allen, Iii

Gregory Allan Hudalla

Jae-Sam Lee

Sharon Virginia Schulzki

Matthew T Dearing

Victoria Harms

Gabriel C Spalding

David Gregory Belair

Stephn E Feinberg

Disclosed are formulations for providing an active agent. Formulations include a carrier including an active agent and mineral coated microparticles wherein an active agent is adsorbed to the mineral. Other formulations include a carrier including mineral coated microparticles wherein mineral coated microparticles include an active agent. Also disclosed are methods for sustained delivery of an active agent and methods for treating inflammatory diseases using a formulation for providing sustained delivery of an active agent.

Mineral coated microparticles for sustained delivery of biologically active molecules

Disclosed are compositions and methods for pluripotent stem cell culture. Compositions include mineral coated microparticles having a core and a mineral coating, wherein the mineral coating includes fibroblast growth factor. Also disclosed are methods for pluripotent stem cell culture methods using mineral coated microparticles including fibroblast growth factor.

Structured nanocoatings for the stabilization of pluripotent stem cell media components

The present invention relates to methods for deriving human hematopoietic progenitors, primitive macrophages, and microglial cells from human pluripotent stem cells. In particular, provided herein are highly efficient and reproducible methods of obtaining human primitive macrophages and microglia from human pluripotent stem cells, where the primitive macrophages and microglia can be suitable for clinically relevant therapeutic applications.

Derivation of human microglia from pluripotent stem cells

The present invention provides methods of differentiating pericytes from pluripotent stem cells comprising culturing steps in chemically defined culture medium. A population of exogenously derived pericytes from PSCs are also contemplated. Further uses of the exogenously cultured pericytes for an in vitro disease model or in vitro angiogenesis assay are contemplated, including an in vitro 3D model of vasculature.

Chemically defined differentiation protocol for pericyte differentiation from pluripotent stem cells

Decellularized plant tissues and the use of these plant tissues as scaffolds are disclosed herein. Particularly, decellularized plant tissues are functionalized such to allow for human cell adhesion, thereby allowing for their use as scaffolds for human cells. These scaffolds can then be used in a number of applications/markets, including as research tools for tissue engineering, regenerative medicine, and basic cellular biology.

Functionalization of plant tissues for human cell expansion

Provided is a composition for a scaffold having a mineral coating similar to bone. Also provided is a method for mineral coating a scaffold so as to promote mineral coating of the scaffold with a plate-like nanostructure and a carbonate-substituted, calcium-deficient hydroxyapatite phase.

Mineral coated scaffolds

The present invention relates to substantially planar vascularized brain cancer organoid and methods of using such vascularized brain cancer organoids in anti-cancer drug discovery screen. In particular, provided herein are methods of producing and using complex, highly uniform vascularized brain cancer organoids that comprise physiologically relevant human cells and have the high degree of sample uniformity and reproducibility required for use in high-throughput screening applications.

Human pluripotent stem cell-derived brain organoids for cancer modeling and drug screening

Provided are biocompatible and implantable scaffolds for treating a tissue defect, such as a bone gap. The scaffolds can have a modular design comprising a tissue scaffold rack designed to accommodate one or more modules. Also provided are methods for fabrication and use of such scaffolds.

Modular tissue scaffolds

Disclosed are compositions and methods for the co-delivery of ribonucleic acids and interferon binding proteins. Compositions include mineral coated microparticles having a mineral layer, a ribonucleic acid, and an interferon binding protein. Ribonucleic acids and interferon binding proteins can be adsorbed to the mineral layer, can be incorporated into the mineral Layer, and combinations thereof. Also disclosed are methods for co-delivery of ribonucleic acids and interferon binding proteins and methods for treating inflammatory diseases using mineral coated microparticles having a mineral layer to provide co-delivery of ribonucleic acids and interferon binding proteins.

Mineral coated microparticles for co-delivery of anti-inflammatory molecules with nucleic acids to improve gene delivery outcomes

Disclosed are formulations for providing a therapeutic bioactive polypeptide to injured tissue. Formulations include mineral coated microparticles wherein a polynucleotide is adsorbed to the mineral layer. Other formulations include a carrier including mineral coated microparticles wherein mineral coated microparticles include a polynucleotide. Also disclosed are methods for sustained delivery of a bioactive polypeptide and methods for treating chronic wounds using a formulation for providing sustained delivery of the bioactive peptide.

Mineral coated microparticles for gene delivery in chronic wound therapy

Provided is a microsphere comprising a bead coated with a first calcium-containing mineral. Also provided is a method of producing a microsphere. Additionally, a method of administering a compound to a vertebrate is provided.

Mineral-coated microspheres

Provided are compositions and methods for a scaffold coated with a primer coating and a mineral coating. Also provided is a composition for a scaffold having a mineral coating similar to bone. Also provided is a method for mineral coating a scaffold so as to promote mineral coating of the scaffold with a plate-like nanostructure and a carbonate-substituted, calcium-deficient hydroxyapatite phase.

Coating scaffolds

Random copolymers, crosslinked thin films of the random copolymers and cell culture substrates comprising the crosslinked thin films are provided. Also provided are methods of making and using the copolymers, thin films and substrates. The copolymers are polymerized from glycidyl methacrylate monomers and vinyl azlactone monomers. The crosslinked thin films are substrate independent, in that they need not be covalently bound to a substrate to form a stable film on the substrate surface.

Azlactone based thermally crosslinkable polymer coating for controlling cell behavior

Growing community of inventors

Waunakee, WI, United States of America

William Leo Murphy