Tearscience, Inc.

Titan Medical Inc.

Optimum Technologies, Inc.

Robert Bosch Start-up Platform North America, Llc, Series 1

William L Weber

Randal B Chinnock

Donald R Korb

Stephen Michael Grenon

Benjamin T Gravely

George Grubner

Jason P Julian

Michael Zelina

Todd Louis Harris

Audrey Steever

Frederick G Bargoot

Stephen M Grenon

Sarah Latta

Steven M Grenon

Ocular surface interferometry devices, systems, and methods are disclosed for imaging an ocular tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image, wherein the specularly reflected light may be produced from various portions of the ocular tear film by obliquely illuminating various portions of the ocular tear film with a multi-wavelength light source, such as in a tiling pattern(s). The imaging device can also be focused on the lipid layer to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image, which can used to measure a tear film layer thickness.

Ocular surface interferometry (OSI) for imaging, processing, and/or displaying an ocular tear film

An illuminator apparatus and method for illuminating an object field imaged by a rectangular image sensor having a first aspect ratio is disclosed. The apparatus includes an optical fiber having a proximal end disposed to receive a plurality of input light beams, each light beam having differing spectral properties, the optical fiber being operable to transmit the light beams along the fiber to a distal end of the optical fiber. The apparatus also includes an integrating element disposed to receive the light beams from the distal end of the fiber and combine the light beams to produce a generally homogenous illumination beam at a rectangular output face of the integrating element. The apparatus further includes an illumination projector operable to project an image of the output face of the integrating element into the object field to produce a generally rectangular illuminated region of the object field substantially corresponding to the portion of the object field imaged by the rectangular image sensor.

Method and apparatus for illuminating an object field imaged by an image sensor

A spreading optics system distributes electromagnetic (EM) waves emitted by an emitter having an emission vector. The spreading optics system includes reflective surfaces. The reflective surfaces include concave first reflector having a concave cross section in a plane substantially perpendicular the emission vector. The reflective surfaces further include a convex second reflector arranged further from the emitter than the concave first reflector. The convex second reflector has a convex cross section in a second plane substantially parallel the first plane. The reflective surfaces are configured to divergently redirect the EM waves into a vector fan at a predetermined angle relative to the emission vector.

Luminaire

Method and apparatus for illuminating an object field imaged by a rectangular image sensor

A stereoscopic image sensor apparatus including a pair of image sensors adjacently fabricated on a common carrier is disclosed, the common carrier being a diced portion of a carrier on which an aligned plurality of image sensors have been fabricated within an alignment tolerance, the alignment tolerance including a target lateral offset between the adjacent image sensors, and a target orientation between corresponding rows of light sensitive elements on the adjacent image sensors. An alternative stereoscopic image sensor apparatus includes a common window having first and second image sensors bonded to the common window within the alignment tolerance. Another alternative stereoscopic image sensor apparatus includes rear faces of respective first and second image sensors being bonded to a common circuit substrate within the alignment tolerance. Methods for fabricating the stereoscopic image sensors are also disclosed.

Stereoscopic imaging sensor apparatus and method for fabricating pairs of image sensors used in stereoscopic imaging

Ocular surface interferometry (OSI) devices and systems for imaging, processing, and/or displaying an ocular tear film

Background reduction apparatuses and methods of Ocular Surface Interferometry (OSI) employing polarization are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT) and can be used to evaluate and potentially diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in at least one image. The at least one image can be processed and analyzed to measure a tear film layer thickness (TFLT), including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT).

Background reduction apparatuses and methods of ocular surface interferometry (OSI) employing polarization for imaging, processing, and/or displaying an ocular tear film

Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). The measured TFLT can be used to diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device can also be focused on the lipid layer of the tear film to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image. The resulting image can be processed and analyzed to measure a tear film layer thickness (TFLT), including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT).

Background reduction apparatuses and methods of Ocular surface interferometry (OSI) employing polarization are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT) and can be used to evaluate and potentially diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in at least one image. The at least one image can be processed and analyzed to measure a tear film layer thickness (TFLT), including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT).

A camera for capturing an image of an object, for example an eye. The camera has at least two light sources and an image-sensing system having two image sensors. A multiple branch optical system transmits outgoing light from the light sources to the object, and transmits incoming light from the object to the image-sensing system. The multiple branch optical system includes an autofocusing element such as a variable power optical element that varies the focus of the incoming light. There is also an image display. There is a controller that controls the operation of the light sources, controls acquisition of images by the image-sensing system, and controls the display of images on the image display. The controller activates an autofocus light source and uses the resulting captured image to automatically adjust the image exposure parameters. The controller automatically adjusts the autofocusing element to improve the image focus, and then activates the second light source and acquires one or more images of the object while the second light source is activated.

Growing community of inventors

Olivebridge, NY, United States of America

William L Weber