Other

Janos Technology Inc.

William L Truett

Christopher D Prozzo

Barry O'Dwyer

Christopher C Alexay

Jeffrey L Tosi

Processes for preparing compounds having two or three antibiotic functionalities using quinolone derivatives, &bgr;-lactams and vancomycin and the like as the starting materials and chloride linking agents; and the novel compounds prepared by these processes, are disclosed.

Compounds formed from two or three antibiotics and their processes of preparation

A series of novel antivirals are disclosed intended to attack a broad range of DNA and RNA viruses, in which nucleosides closely related entities are linked via reaction with a diacid chloride of the general structure COCl--(CH.sub.2).sub.n --COCl wherein n is two or greater.

Antivirals and process for preparation

A method for spectral analysis of mixtures is disclosed using thin layer chromatography for separation of the components of the mixture followed by taking FTIR spectroscopic readings along the vertical length of the coated support.

Apparatus and method for thin layer chromatography

A method of analyzing a specimen by infrared spectroscopy is disclosed wherein a specimen support having a plurality of unobstructed holes of substantially uniform size and a film of the specimen enclosing each hole is positioned vertically in the spectrometer and a beam of infrared light is directed through the holes to generate a wavelength spectrum characteristic of the specimen.

Screen cell and method of using

A group of reagents, as diisocyanates, dianhydrides, diacidchlorides, diepoxides, carbodiimides and the like are utilized to link a wide variety of antibiotic moities, reacted two at a time with said reagents, the said antibiotic moieties containing groups reactive with the linking reagents as carboxylic acid, alcolhol, primary amine, and secondary amine functional groups, said functional groups being present as singularities or as multiplicities, products being readily purified using chromatographic techniques, and said products of above reactions being valuable for the treatment of microbial infections of man and animals.

Antibiotics and process for preparation

A series of organic test papers are described for the detection and identification of all types of organic compounds such as aldehydes, ketones, esters, acids, amines, isocyanates, anhydrides, amides, nitrides, aromatics, phenols, ethers, and other organic compounds, said test papers comprising an absorbent paper or microporous plastic impregnated with a reagent or reagents capable of reacting with a class of organic compounds. The method of using the test papers for the identification of organic compounds comprises making a presumptive identification of the class of the unknown sample using FTIR spectroscopy, and then placing this presumptively identified sample onto the paper to generate a new substance known as a derivative of the organic compound, which aids in the identification of the unknown organic compound. The test paper containing said sample and reagent is then monitored again using FTIR spectroscopy to observe the reaction and to verify the presumptively identified substance's class identification.

Organic chemical compound test papers and method of using same

The device of the invention employs a small Teflon.RTM. vial which is mounted in a vertical position in a plastic box, and a segment of screen attached to a rod which can be raised or lowered into the reaction vessel which contains liquid reactants. When raised, the screen carries a sample into a portion of the vessel having IR transparent parts, axially aligned with corresponding parts in the plastic outer container. The device is positioned in an FTIR spectrometer. Data obtained from successive IR scans are used to follow the progress of a chemical reaction.

FTIR chemical reaction monitor

There is described within a portable, battery-powered multiple filter infrared spectrometer consisting of a highly efficient optical system employing an infrared source with a chopper, from which IR energy passes through compound parabolic concentrators (CPC's) and is directed by a beamsplitter to the external sample, where the beam intersects with the sample via reflection and is returned through the CPC and beamsplitter to a stationary filter assembly and discrete detector array where the energy is converted to an A.C. (alternating current) signal. This current energizes an LED bar graph display for spectral identification. This method and apparatus is used to determine IR spectra of solids, liquids on a mirror, and gases in a container with a mirror to reflect light.

Portable filter infrared spectrometer

A specimen support for optical observation or analysis is disclosed. The support comprises a disc-like member composed of a rigid material and having a plurality of holes extending therethrough, preferably in a screen of substantially equal-sized holes. When analyzing a liquid specimen, the disc is dipped in the liquid and the surface tension of the liquid will cause the liquid to bridge or span the holes. The support is then placed vertically in a tray or holder and exposed to an infrared beam that passes horizontally through the holes to generate an infrared spectrum.

Screen cell for spectroscopy

A positioning device for optimal positioning of infrared accessories, usable in all FTIR spectrometers, in the X-Y-Z planes of the spectrometer with an additional angular adjustment in the X-Y plane in order to optimize the infrared energy reaching the spectrometer detector. All accessories are mounted on the sample stage of the positioning device by means of a single positioning pin and all accessories are equipped with a blocking shield which assures that all energy which reaches the detector of the spectrometer has transited the attenuated total reflectance crystal.

Growing community of inventors

West Brattleboro, VT, United States of America

William L Truett