Merck + Co., Inc.

William L Laswell

George D Hartman

Mark E Duggan

Ralph P Volante

Melissa S Egbertson

Ichiro Shinkai

Wasyl Halczenko

Joseph E Lynch

David M Tschaen

Laura M Turchi

A series of non-peptide derivatives that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet anti-aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation.

Sulfonamide fibrinogen receptor antagonists

A series of non-peptide derivatives that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation.

Fibrinogen receptor antagonists

The 4-acyloxyazetidin-2-ones, which are intermediates in the production of carbapenems and penems, are produced from nitrogen deprotected 4-furanylazetidin-2-ones.

Nitrogen deprotected 4-acyloxyazetidin-2-ones

A process is described for the stereocontrolled synthesis of (3R,4R)-3-[(1R)-1-hydroxyethyl]-4-benzoyloxyazetidin-2-ones and their derivatives by cycloaddition involving an imine and a ketone, generated from 3(S)-hydroxybutyrate which are useful intermediates in the synthesis of carbapenem antibiotics.

Stereoselective synthesis of a chiral cis 3-beta hydrogen (3R)

The 4-acryloxyazetidin-2-ones, which are intermediates in the production of carbapenems and penems, are produced from 4-furanylazetidin-2-ones by electrochemical methods.

Process for the preparation of 4-acyloxyazetidin-2-one by

The 4-acyloxyazetidin-2-ones, which are intermediates in the production of carbapenems and penems, are produced from 4-furanylazetidin-2-ones by singlet oxygen oxidation.

Process for the preparation of 4-acyloxyazetidin-2-one by singlet oxygen

The 4-acyloxyazetidin-2-ones, which are intermediates in the production of carbapenems and penems, are produced from 4-furanylazetidin-2-ones by a sequential oxidation-reduction-oxidation reaction scheme.

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Perkasie, PA, United States of America

William L Laswell