Novartis Ag

Sandoz Gmbh

Glaxo Wellcome Inc.

Affymax, Inc.

William L Fitch

Rakesh K Jain

Ralston Curtis

David C Creech

Mark A Gallop

Eric M Gordon

Christopher P Holmes

Derek Maclean

Zhi-Jie Ni

Nikhil Shah

Kenneth C Lewis

Frank R Holden

Devices and methods are provided to facilitate the evaluation of the quality of a combinatorial library of compounds. One exemplary device comprises a holding plate having an array of apertures. A plurality of vials are removably held within the apertures. Each of the vials has an open top end. A seal member is disposed over the top ends of the vials, and a top plate is removably coupled to the holding plate to force the seal member against the top ends of the vials.

Apparatus and methods for evaluating the quality of a combinatorial library of compounds

Disclosed are chemical encryption methods for determining the structure of compounds formed in situ on solid supports by the use of specific amines tags which, after compound synthesis, can be deencrypted to provide the structure of the compound found on the support.

Methods for hard-tagging an encoded synthetic library

Microcapsules formed from urea-, thiourea- and/or melamine-formaldehyde prepolymers which are particularly useful in formulating agrochemicals.

Microcapsules

Process for producing microcapsules

Growing community of inventors

Palo Alto, CA, United States of America

William L Fitch