Biochem Pharma Inc.

Astra Ab

William L Brown

Nghe Nguyen-Ba

Gervais Dionne

Miguel Quimpere

Laval Chan Kong

Laval Chan Chun Kong

Peter W Schiller

Nucleotide analogues having the general formula (I) and pharmaceutically acceptable derivatives:

Process for preparing antiviral 2-phosponate nucleotide analogs

Nucleotide analogues having the general formula (I) and pharmaceutically acceptable derivatives: ##STR1## wherein n is 0 or an integer; X is O or S, CH.sub.2, CH--halogen, CH--N.sub.3, or C.dbd.CH.sub.2 ;

Antiviral compounds

Nucleotide analogues having the general formula (I) and pharmaceutically acceptable derivatives: ##STR1## wherein n is 0 or an integer; X is O or S, CH.sub.2, CH-halogen, CH--N.sub.3, or C.dbd.CH.sub.2 ;

This invention relates to novel dermorphin analogs having pharmacological activity. More particularly, this invention relates to novel tetrapeptides having specific structural features and a net charge of +2 or greater. The peptides of this invention are useful in treating pain and gastro-intestinal disorders. Accordingly, this invention also relates to pharmaceutical compositions comprising those peptides and methods for treating pain and gastro-intestinal disorders.

Growing community of inventors

Laval, Canada

William L Brown