Vtv Therapeutics LLC

Transtech Pharma, Inc.

High Point Pharmaceuticals, LLC

William Kenneth Banner

Robert Carl Andrews

Anitha Hari

Raju Bore Gowda

Dharma Rao Polisetti

Bapu Reddy Gaddam

Suparna Gupta

Mohan Rao

Devi Reddy Gohimukkula

David R Jones

Jeff Jiqun Zhu

Muralidhar Bondlela

Rongyuan Xie

Jeremy T Cooper

Ghassan Qabaja

Pingzhen Wang

Kurt Sundermann

Adnan M M Mjalli

Samuel F Victory

Daniel Peter Christen

Tan Ren

Adnan Mm Mjalli

Samuel Victory

Soumya P Sahoo

David Jones

Daniel P Christen

Bapu Gaddam

Robert C Andrews

Daniel Christen

Adnan MM Mjalli

The present invention relates to metabolites of [3-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine. These metabolites may act as RAGE antagonists. These metabolites may also be useful in assays to measure the presence or amount of one or more metabolites of the parent compound in a sample.

Metabolites of [3-(4-(2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4-yl)-phenoxy)-propyl]-diethyl-amine

Metabolites of [3-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4 yl}-phenoxy)-propyl]-diethyl-amine

The present invention provides N-[1-(1-Cyclohexyl-3,5-dimethyl-1H-pyrazole-4-sulfonyl)-4-phenyl-piperidin-4-ylmethyl]-N-isobutyl-4-{[(piperidin-4-ylmethyl)-amino]-methyl}-benzenesulfonamide and pharmaceutically acceptable salts thereof. These compounds may be useful in the treatment of diseases such as Alzheimer's disease or renal failure. The present invention further relates to methods for the preparation of compounds of Formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and the use of such compounds and/or pharmaceutical compositions in treating certain diseases.

Piperidine derivative and methods of use thereof

The present invention provides phenyl-heteroaryl derivatives of Formula (I) and pharmaceutically acceptable salts thereof These compounds are useful in the treatment of RAGE-mediated diseases. The present invention further relates to methods for the preparation of compounds of Formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and the use of such compounds and/or pharmaceutical compositions in treating RAGE-mediated diseases.

Phenyl-heteroaryl derivatives and methods of use thereof

The present invention provides phenyl-heteroaryl derivatives of Formula (I) and pharmaceutically acceptable salts thereof These compounds are useful in the treatment of RAGE-mediated diseases such as Alzheimer's Disease. The present invention further relates to methods for the preparation of compounds of Formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and the use of such compounds and/or pharmaceutical compositions in treating RAGE-mediated diseases.

The present invention provides substituted imidazo[1,2-b]pyridazine derivatives, pharmaceutically acceptable salts thereof, and tautomers of any of the foregoing, where such compounds inhibit &#x3b2;-site amyloid precursor protein-cleaving enzyme (BACE), which may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease. The invention also provides pharmaceutical compositions comprising any of these compounds and the use of any of these compounds and compositions in the treatment of diseases, disorders, or conditions in which BACE is involved.

Substituted imidazo[1,2-b]pyridazine derivatives, pharmaceutical compositions, and methods of use as &#x3b2;-secretase inhibitors

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Greensboro, NC, United States of America

William Kenneth Banner