Sigma-aldrich Co. LLC

William Karl Kappel

Handong Li

John G Dapron

Richard J Mehigh

Venkatappa Viswanatha

Vankatappa Viswanatha

A metal chelating composition having the formula: wherein

Metal chelating compositions for protein purification, detection or binding

A metal chelating composition having the formula:wherein

A high capacity assay platform capable of binding target molecules includes a substrate and a polymer matrix attached to the substrate. The polymer matrix comprises a plurality of polymer molecules where at least some of the polymer molecules are covalently attached directly to the substrate and at least some of which molecules are crosslinked to other polymer molecules. Some of the polymer molecules have at least one binding ligand covalently attached thereto, and the density of the polymer matrix on the substrate is at least 2 &mgr;g/cm .

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Oakville, MO, United States of America

William Karl Kappel