Other

Citrix Systems, Inc.

Linnet Biopharmaceuticals, Inc.

Alhamadsheh, Mamoun, M.

William K Chan

Chiradeep Vittal

Alex Huang

Xiaoling Li

Mamoun M Alhamadsheh

Mark R Miller

Sravan C Penchala

Miki S Park

Stan W Linnet

Timothy N Linnet

Liang Xue

The teachings provide methods of delivering active agents that are conjugated with delivery systems that increase the half-life, and reduce the immunogenicity, of the active agents. Delivery systems and methods of making and using the delivery systems are also provided. The delivery systems have (i) a ligand that is selective for an endogeneous plasma protein in the serum of a subject; and, (ii) a linker configured for operatively attaching the ligand covalently to an active agent to increase the half-life of the active agent in the serum.

Enhanced SN-38 anticancer agent

A cloud system may create and support multiple network offerings for virtual machines in a cloud zone. Physical networks comprising sets of network elements, such as routers, gateways, firewalls, load balancers, and other network hardware, may be created and updated within a zone. Network offerings may be defined and associated, using tags or other techniques, with virtual machine networks, physical networks and/or network elements. Cloud end users may request specific network offerings when creating virtual machines, or may request to move existing virtual machines from one network offering to another. The cloud system may use the requested network offering to identify the virtual machine network, physical network, and/or network elements corresponding to the requested network offering. The cloud system may allocate a new virtual machine network and configure the network elements within the associated physical network to provide network services to the virtual machine.

Network offering in cloud computing environment

Enhanced anticancer agent

Delivering enhanced active agents

The teachings provide active agents that are conjugated with delivery systems that increase the half-life, and reduce the immunogenicity, of the active agents. Methods of making and using the systems are also provided. The delivery systems have (i) a ligand that is selective for an endogeneous plasma protein in the serum of a subject; and, (ii) a linker configured for operatively attaching the ligand covalently to an active agent to increase the half-life of the active agent in the serum.

Enhanced active agents

A delivery system for active agents, and methods of making and using the systems, are provided. The delivery systems have (i) a ligand that is selective for an endogeneous plasma protein in the serum of a subject; and, (ii) a linker configured for operatively attaching the ligand covalently to an active agent to increase the half-life of the active agent in the serum.

Systems for stabilizing and delivering active agents

Methods and systems for managing cloud zones are described herein. A management server for a cloud of computing resources may add private zones to the cloud. The private zones may contain computers owned and operated by a user of the cloud, such as a cloud customer, rather than the cloud operator. The management server may manage the computing resources in the private zone by sending commands to an agent, which in turn relays the management server's commands to the individual computing resources. The agent may be authenticated using a token.

Managing cloud zones

Methods and systems for management of cloud computing resources are described herein. A management server for a cloud of physical computing resources may assign states to individual physical computing resources or groups of physical computing resources. The states may include a disabled state, in which only administrator access to the resources is permitted; an enabled state, in which user access to the resources is permitted; a restricted state, in which some, but not all user requests to the resources are permitted; and an unmanaged state, in which no communications between the resources and the management server are permitted.

Assigning states to cloud resources

A cloud system may create physical resource tags to store relationships between cloud computing offerings, such as computing service offerings, storage offerings, and network offerings, and the specific physical resources in the cloud computing environment. Cloud computing offerings may be presented to cloud customers, the offerings corresponding to various combinations of computing services, storage, networking, and other hardware or software resources. After a customer selects one or more cloud computing offerings, a cloud resource manager or other component within the cloud infrastructure may retrieve a set of tags and determine a set of physical hardware resources associated with the selected offerings. The physical hardware resources associated with the selected offerings may be subsequently used to provision and create the new virtual machine and its operating environment.

Virtual machine provisioning based on tagged physical resources in a cloud computing environment

The teachings provided herein generally relate to compositions comprising rutaecarpine derivatives that activates CYP1A2 through enzyme induction. The uses for such a derivative can include removing caffeine from a subject, improving sleep, treating insomnia, treating caffeine toxicity, treating caffeine addiction and withdrawal symptoms, and the like. Caffeine is just one example of a substrate that can be removed using the derivatives taught herein, and other examples, including theophylline, are provided herein.

Growing community of inventors

Elk Grove, CA, United States of America

William K Chan