The General Hospital Corporation

Tufts University

William Joseph Brunken

Robert E Burgeson

Manuel Koch

Dale D Hunter

Pamela Olson

Douglas R Keene

Marie-France Champliaud

Leena Bruckner-Tuderman

Richard R Libby

&#x3b2;-netrin nucleic acid molecules and polypeptides are provided. Methods of using the &#x3b2;-netrin nucleic acid molecules and polypeptides are also provided.

&#x3b2; netrin and uses thereof

The invention provides isolated nucleic acids molecules, designated collagen XXII nucleic acid molecules, which encode a novel collagen. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing collagen XXII nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a collagen XXII gene has been introduced or disrupted. The invention still further provides isolated collagen XXII proteins, fusion proteins, antigenic-peptides and anti-collagen XXII antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Collagen XXII, a novel human collagen and uses thereof

&#x3b2;-netrin and uses thereof

The invention provides isolated nucleic acids molecules, designated collagen XXII nucleic acid molecules, which encode a novel collagen. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing collagen XXII nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a collagen XXII gene has been introduced or disrupted. The invention still further provides isolated collagen XXII proteins, fusion proteins, antigenic peptides and anti-collagen XXII antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

The present invention features two members of laminin family, i.e., laminin 13 and laminin 14, the methods of making these molecules, and the methods of using these molecules in treating neural disorders, e.g., retinal disorders. The present invention also features using a preparation of laminin 5 to treat neural disorders, especially disorders associated with retina.

Laminin 5, 13 and 14 and uses thereof

The present invention is based on the discovery of a novel member of the laminin family, laminin 12. Accordingly, the present invention features a purified or isolated preparation or a recombinant preparation of laminin 12 which includes an &agr;2 subunit, &bgr;1 subunit and a &ggr;3 subunit.

Laminins and uses thereof

The present invention features a novel member of the laminin family, i.e., laminin 15, the methods of making these molecules, and the methods of using these molecules in treating neural disorders, e.g., retinal disorders.

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Canton, MA, United States of America

William Joseph Brunken