Oxford Gene Technology Limited

Amersham International Plc

Amersham Pharmacia Biotech UK Limited

Nycomed Amersham Plc

William Jonathan Cummins

Edwin M Southern

Alan L Hamilton

John Anthony Smith

Richard West

Shiv R Kumar

Mark McDougall

Satyam Nampalli

David Loakes

Clifford Leslie Smith

Adrian Christopher Simmonds

Daniel M Brown

Mark Samuel Briggs

Ian Edward Bruce

Fergal Hill

Christopher Robert Mundy

David Williams

Richard Martin West

Gerard Philip Brophy

Patrick Finn

Peter Jackson

Mark Samuel Jonathan Briggs

Nucleoside analogues have structure (2) wherein Q is H or a sugar moiety or sugar analogue or a modified sugar or a nucleic backbone or backbone analogue, W is an alkylene or alkenylene chain of 0-5 carbon atoms, any of which may carry a substituent R , X is O or N or NR or CR , X&prime; is O or S or N, provided that when X&prime; is O or S, then X is C, Y is CH or N, R is NH or SMe or SO Me or NHNH , each of R and R is independently H or F or alkyl or alkenyl or aryl or acyl or a reporter moiety, R is independently H or alkyl or alkenyl or aryl or acyl or a reporter moiety, and R is H or &boxH;O or F or alkyl or aryl or a reporter moiety.

Tricyclic base analogues

This invention provides reagents, libraries and sets of the reagents, and assay methods using the reagents, the reagents comprising an analyte moiety and a tag moiety, wherein the tag moiety contains information defining the identify and location of the analyte residues of the analyte moiety which is detectable by mass spectrometry.

Tag reagent and assay method

Cyanine dyes

The present invention discloses a method of separating or distinguishing carbohydrate substances. More particularly the method includes using fluorescent labeling reagents which have a positive charge when bound to a carbohydrate, involves separating the labeled carbohydrate substances, such as by performing electrophoresis to cause differential migration of different labeled carbohydrate substances, or by isoelectric focusing in a pH gradient. The fluorescent labeling reagents are preferably cyanine dyes.

Analysis of carbohydrates

Squarate dyes and their use in fluorescent sequencing method

A method of assaying for CAT in a fluid involves the use of a complex of chloramphenicol with a member of a specific binding pair such as a hapten or biotin. Biotinylated chloramphenicol is claimed as new. A scintillation proximity assay involves use of this reagent with tritiated acetyl coenzyme A and streptavidin coated SPA beads.

Cat assay

Growing community of inventors

Tring, United Kingdom

William Jonathan Cummins