Imperial Chemical Industries Limited

Zeneca Limited

William J Watkins

Gareth Morse Davies

James Kenneth Sutherland

George A Snow

George R Brown

Alan Wellington Faull

David Waterson

Keith Russell

Robin Wood

Nicholas John Newcombe

Elaine Sophie Elizabeth Stokes

John Graham Cumming

Heterocyclic compounds useful as pharmaceutical agents

The invention concerns novel 1,3-dioxane alkenoic acid derivatives of the formula I ##STR1## wherein: n is the integer 1 or 2; Y is methyleneoxy, vinylene or ethylene;

Heterocyclic acids

6-Fluoroshikimic acid derivatives of the formula (I): ##STR1## wherein R.sup.1 is hydroxy or a moiety biotransformable thereto and R.sup.2 is hydrogen or --P(O)(OH).sub.2 have antibacterial, antifungal and herbicidal activity. Their preparation and use are described as are pharmaceutical compositions containing them.

Compounds useful as intermediates in the synthesis of shikimic acid

6-Fluoroshikimic acid derivatives of the formula (I): ##STR1## wherein R.sup.1 is hydroxy or a moiety biotransformable thereto and R.sup.2 is hydrogen or --P(O)(OH).sub.2 have antibacterial, antifungal, and herbicidal activity. Their preparation and use are described as are pharmaceutical compositions containing them.

6-Fluoro-shikimic acid derivatives, pharmaceutical compositions and use

Growing community of inventors

Macclesfield, United Kingdom

William J Watkins