Ciba Corning Diagnostics Corp.

Chiron Diagnostics Corporation

Other

United Technologies Corporation

Raytheon Technologies Corporation

William J Riordan

Uri Piran

Federico Papa

Laurie A Livshin

Joseph D Evetts

Richard A Martinelli

John T Unger

Steve C Chang

Raymod Alan Laird

Edward M Sunshine

James W Peterson

Deborah R Silbert-Shostek

A simple low-cost portable method for golfers to be active in the management of interval time. In particular, the method has golfer groups with a scannable code and uses simple off-the-shelf electronics on the golf course to capture data used to determine interval time. The interval time is available to determine same day consequences for long interval time as well as interval time of a golfer whereby interval time of the golfer influences access to tee times and position on the tee sheet for tournaments. Additionally, golf course management uses of interval time of golfers whereby available tee times are increased and golfer experience is improved.

Portable method for managing interval time for golfers

A method of cooling a gas turbine engine case assembly includes moving a fan air valve that is operatively connected to a pre-cooler having a bypass inlet that is configured to receive bypass air that bypasses a gas turbine engine core to facilitate a provision of bypass air through a fan air valve inlet to the bypass inlet to a first open position, in response to a core compartment temperature being greater than a target core compartment temperature. The method further includes bleeding the bypass air through a bypass outlet of the pre-cooler into a core compartment.

Gas turbine engine and method to cool a gas turbine engine case assembly

A method of cooling a gas turbine engine case assembly includes moving a fan air valve that is operatively connected to a precooler having a bypass inlet that is configured to receive bypass air that bypasses a gas turbine engine core to facilitate a provision of bypass air through a fan air valve inlet to the bypass inlet to a first open position, in response to a core compartment temperature being greater than a target core compartment temperature. The method further includes bleeding the bypass air through a bypass outlet of the precooler into a core compartment.

A method and kit for mounting a flag to a flagpole includes providing a mounting kit having a flagpole, a sealed bearing with an inside diameter dimension selected to correspond to an outside diameter dimension of the flagpole; a tie; a flexible coupler and a flag with a sufficiently stiff pole-side hemmed edge extending between a top flag eyelet and a bottom flag eyelet to help hold the pole-side hemmed edge straight for full flag display purposes; and then, following the instructions within the kit, mounting the flagpole to a stationary surface, securing the sealed bearing to a top portion of the flagpole, passing the tie through the top one of the pair of flag eyelets to secure a top portion of the flag to the bearing with the tie; and securing the flexible coupler between the bottom one of the pair of eyelets and the flagpole, thereby mounting the flag for free rotation about the flagpole in windy conditions.

Flag mounting kit and method of using same

A new method for immobilization of small molecules on solid supports via a macromolecular spacer has been developed. A protein or another macromolecule is first immobilized in an aqueous medium, and the solid support is than washed with an organic solvent. The small molecule is coupled in an organic medium, followed by organic medium washes. The new solid phases are useful for affinity purifications, immunoassays and other binding assays, and for selection of binders by panning procedures.

Conjugation of ligand to immobilized protein in organic solvent

Novel non-competitive assay techniques have been developed which not only improve sensitivity, but also are convenient and less susceptible to interfering factors. They are compatible with existing instruments and can be run in one or more test tubes. The analyte is reacted with labeled specific binder, after which the mixture is reacted with (1) an insoluble material attached to an analyte derivative and (2) a solid phase carrying a binder. The solid phase is then separated, and the label attached to the solid phase is measured. Variations of the procedure include the use of a reversible bridge for attaching the insoluble material to the analyte mimic and the conduct of the assay in various porous media, such as paper, chromatographic and electrophoretic media, and dipsticks.

Reduction of background in noncompetitive binding assays

A novel non-competitive immunoassay technique has been developed which not only improves sensitivity, but also is convenient and less susceptible to interfering factors. It is compatible with existing instruments and is an assay that can be run in one test tube. The analyte is reacted with labeled specific binder, after which the mixture is reacted with (1) an insoluble material attached to an analyte derivative and (2) a solid phase carrying a binder. The solid phase is then separated, and the label attached to the solid phase is measured.

Method for non-competitive binding assays

This invention relates to methods that have been found useful in reducing non-specific binding in immunochemical assays, via methods that can be implemented much faster than those used by Ishikawa. The techniques include the use of a lipophilic bridge, such as a liposome, or the elution of the antigen-antibody complex from the solid phase by the use of an anti-idiotypic antibody or an antibody, or the use of a heterologous reversible bridge.

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Boston, MA, United States of America

William J Riordan