The Coca-cola Company

National Institutes of Health, a Component of the US Dept. of Health & Human Services

University of Pennsylvania

Vanderbilt University

The Uab Research Foundation

Other

University of California

University of Pittsburgh

Marmon Foodservice Technologies, Inc.

The United States of America,as Represented by the Secretary, Department of Health and Human Servic

William J Moore

Alex Gregory Waterson

Anton Simeonov

David Joseph Maloney

Gary Allen Sulikowski

Ajit Jadhav

Kwangho Kim

Leonard M Neckers

Xin Hu

Plamen P Christov

Daniel Jason Urban

Shyh Ming Yang

Kyle Ryan Brimacombe

Victor M Darley-Usmar

Somnath Jana

Chi V Dang

Bryan T Mott

Ganesh Rai Bantukallu

Jennifer L Kouznetsova

C Brad Green

Arthur G Rudick

David R Newman

Gregg Carpenter

David O Slagley

Scott Cuppari

Gene M Farrell

Cynthia D Jones

Peter Wipf

Jonathan Kirschner

Donna Mary Huryn

Neal Green

Dick P Welch

Michelle Arkin

Matthew G LaPorte

Stan C Kaplita

Mary Liang

Kean-Hooi Ang

Raffaele Colombo

Jamal Omari Wilson

Chaemin Lim

Marc Katz

Marina Kovaliov

Eric T Baldwin

Stacie Bulfer

Celeste Natalie Alverez

Zhizhou Yue

Lalith Palitha Samankumara

Alexander Julian Chatterley

Yongzhao Yan

Samuel L Orr

James Alan Sanders

Lindsey Jane Bozung

R Jeffrey Neitz

Clifford Bryant

Indra Prakash

H Brock Kolls

Daniel S Quartarone

Matthew E Hall

Robert D Hughes, Iv

Eric L Pribyl

Joshua Allen Maust

Christopher F Zemko

Ian S Fitzpatrick

Arsalan Aslam

Kurt Zoellick

Michael Jason Goulet

Ganesha Rai Bantukallu

Caitlin Lahey

Victor Henry Quittner

Sandesh Aravinda

Susan R W Lane

Jamal Omarl Wilson

Will Cannon, Iii

Bernard Phoenix

David J Maloney

Robert D Iv Hughes

Christopher Zemko

Matthew Hall

Brian T Mott

Provided is a compound of formula (I) in which Ar, R, U, V, W, X, and p are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer, a method of treating a patient with cancer cells resistant to an anti-cancer agent, and a method of inhibiting lactate dehydrogenase A (LDHA) and/or lactate dehydrogenase B (LDHB) activity in a cell.

Small molecule inhibitors of lactate dehydrogenase and methods of use thereof

A cartridge for dispensing a pre-measured buffering agent together with a medical fluid such as dental anesthetic. The cartridge includes a sharp piercing element at one end, a frangible barrier proximate the piercing element, and a traveling closure. The buffering solution is in a chamber between the barrier and the closure. When loaded into a syringe and subjected to operating pressures, the barrier is pierced, enabling the buffering solution to mix with the medical fluid. Continued pressure propels a desired, controlled mixture into a tissue of a patient. A dye may be included for visual confirmation of mixing. The invention may be regarded as the cartridge, a syringe having the cartridge, or a kit, with or without a syringe, or cartridges having closures of different types.

Buffering agent cartridge

Systems and methods are disclosed herein that include providing a beverage dispensing machine with a cleaning system comprising a first water branch and a second water branch connected in fluid communication with a three-way valve, a cleaning supply connected in fluid communication with the second water branch via a pump, and a nozzle. The three-way valve may be operated in a 'dispensing mode' to provide a flow of at least one of water and carbonated water through the first water branch and a flowpath of the three-way valve to the nozzle, and operated in a “cleaning mode” to provide a flow of a cleaner, and optionally a flow of at least one of water and carbonated water, through the second water branch and a secondary flowpath of the three-way valve to the nozzle to clean the nozzle and/or a drain of the beverage dispensing machine.

Automated cleaning system for beverage dispensing machine

The present application provides a beverage dispensing system. The beverage dispensing system may include a diluent line in communication with a diluent, a flow meter and a variable flow control module positioned on the diluent line, a number of syrup lines in communication with a number of syrups, and a fixed flow control module positioned on the syrup lines. The variable flow control module controls the flow rate of the diluent through the diluent line based upon the flow rate of one of the syrups through one of the syrup lines.

Flexible beverage dispensing system

An insert for use with a beverage dispenser includes a diffuser having an upstream end configured to receive the first base fluid, a downstream end with an outlet configured to dispense the first base fluid, and a center bore extending between the upstream end and the downstream end along an axis. A stem is disposed in the center bore of the diffuser and has a first end configured to receive a second base fluid and an opposite second end with an outlet configured to dispense the second base fluid. The outlet of the diffuser is upstream from the outlet of the stem such that the first base fluid dispensed from the outlet of the diffuser mixes with an additive fluid before the second base fluid dispensed from the outlet of the stem mixes with the additive fluid.

Inserts and nozzle assemblies for beverage dispensers

The present application provides a beverage dispensing system for dispensing beverages with low solubility ingredients. The beverage dispensing system may include a sweetener flow, a first diluent flow, a low solubility ingredient premixing system for mixing a low solubility ingredient with a second diluent flow to create a mixed flow, and a nozzle to mix the sweetener flow, the first diluent flow, and the mixed flow.

Beverage dispenser for dispensing low solubility ingredients

The present invention is directed to methods of inhibiting p97 and compounds and compositions useful in such methods. Diseases and conditions the can be treated with the compounds and compositions of the invention include, but are not limited to, cancer and neurodegenerative disorders susceptible to treatment by inhibition of p97.

Phenyl indole allosteric inhibitors of P97 ATPase

Provided is a compound of formula (I), in which Ar, R, U, V, W, X, and p are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer, a method of treating a patient with cancer cells resistant to an anti-cancer agent, and a method of inhibiting lactate dehydrogenase A (LDHA) and/or lactate dehydrogenase B (LDHB) activity in a cell.

The disclosure provides a compound of the formula (II) and pharmaceutically acceptable salts thereof. The variables, e.g. n, R, R, R, X, Y, and Z are defined herein. These compounds act as lactate dehydrogenase inhibitors and are useful for treating cancer and fibrosis. The compounds may be particularly useful for treating forms of cancer in which a metabolic switch from oxidative phosphorylation to glycolysis has occurred. The disclosure also provides pharmaceutical compositions containing a compound of this formula and method for treating patients having cancer, fibrosis, or other conditions in which a metabolic switch from oxidative phosphorylation to glycolysis has occurred. 

1 H-pyrazol-1-yl-thiazoles as inhibitors of lactate dehydrogenase and methods of use thereof

Systems and methods are disclosed herein that include providing a beverage dispensing machine with a cleaning system comprising a first water branch and a second water branch connected in fluid communication with a three-way valve, a cleaning supply connected in fluid communication with the second water branch via a pump, and a nozzle. The three-way valve may be operated in a 'dispensing mode' to provide a flow of at least one of water and carbonated water through the first water branch and a flowpath of the three-way valve to the nozzle, and operated in a 'cleaning mode' to provide a flow of a cleaner, and optionally a flow of at least one of water and carbonated water, through the second water branch and a secondary flowpath of the three-way valve to the nozzle to clean the nozzle and/or a drain of the beverage dispensing machine.

Phenyl indole allosteric inhibitors of p97 ATPase

Growing community of inventors

Lilburn, GA, United States of America

William J Moore