Siemens Medical Solutions Usa, Inc.

University of California

William J Gibb

Francisco Miguel Hernandez-Guerra

Todd Howard Steinberg

Michael Smidebush

Charles Clark

Loren Lentz

Debra Penny

Joe W Gray

John H Hughes

Laura M Heiser

Rolando R Tayag

Paul T Spellman

Wen-lin Kuo

Nicholas J Wang

Anguraj Sadanandam

Ed San Mateo

Salah Captain

Herein is described the use of a collection of 50 breast cancer cell lines to match responses to 77 conventional and experimental therapeutic agents with transcriptional, proteomic and genomic subtypes found in primary tumors. Almost all compounds produced strong differential responses across the cell lines produced responses that were associated with transcriptional and proteomic subtypes and produced responses that were associated with recurrent genome copy number abnormalities. These associations can now be incorporated into clinical trials that test subtype markers and clinical responses simultaneously.

Molecular predictors of therapeutic response to specific anti-cancer agents

Some embodiments provide a sensor element, a shield element capacitively coupled to the sensor element and to ground, a coupling circuit to receive an input signal, and to electrically couple the received input signal to the sensor element and to the shield element, an output circuit to generate an output signal, the output signal based on a capacitance between the sensor element and an object, and a classifier to determine a material based on the output signal, and to transmit a material signal to the output circuit based on the determined material, wherein the output circuit is adjustable based on the material signal.

Adaptive proximity sensing

A portal imaging device positioning apparatus includes a portal imaging device positioner () attachable to a support (). The portal imaging device positioner () is adapted to vertically adjust an imaging panel () in a treatment or dosimetry mode to receive radiation through a body in the patient plane (), and adjust the panel in a physics mode to receive radiation at the patient plane ().

System and method for positioning an electric portal imaging device

A portal imaging device positioning apparatus includes a portal imaging device positioner ( ) attachable to a support ( ). The portal imaging device positioner ( ) is adapted to vertically adjust an imaging panel ( ) in a treatment or dosimetry mode to receive radiation through a body in the patient plane ( ), and adjust the panel in a physics mode to receive radiation at the patient plane ( ).

System and method for positioning an electronic portal imaging device

A beamblock tray for use with multiple defining heads within a medical linear accelerator is disclosed. The beamblock tray comprises a tray portion, and a plurality of coded connectors coupled to the tray portion that make the tray &ldquo;intelligent&rdquo; enough to identify its orientation to a user. The tray portion can be inserted into the defining head in a plurality of directions based upon the plurality of coded connectors. A system and method in accordance with the present invention utilizes a plurality of coded connectors that can be used to identify a patient. In addition, the connectors and a mounting flange are such that they permit the tray to be inserted in a plurality of directions. Finally, a coding system is provided that prevents radiation from being delivered if the tray is oriented incorrectly. A dual axis beamblock tray in accordance with the present invention circumvents this problem by a counting for the two possible orientations of beamblock tray holders, thereby permitting the radiation therapist to use a single tray with a variety of linear accelerators.

Method and system for multi-axis beamblock tray for multiple defining heads

Growing community of inventors

San Anselmo, CA, United States of America

William J Gibb