Lucent Technologies Inc.

Race Oncology Ltd.

International Mobile Machines Corporation

Delmar Pharmaceuticals, Inc.

Del Mar Pharmaceuticals (bc) Ltd.

William J Garner

John Rothman

Winston Hong Lieu

Amie Franklin

Zhihong Huang

Dennis M Brown

Ilya Alexander Korisch

Jeffrey A Bacha

Richard Schwartz

C Lowell Parsons

Helen Haeran Kim

Sarath Kanekal

Andrew L Adamiecki

Howard A Burris, Iii

Shaun Fouse

Kent C Shih

Arnie Franklin

Anne Steino

Sareth Kanekal

Howard A Burris

Michael Flashner

Amie E Franklin

The present invention describes methods and compositions for improving the therapeutic efficacy of therapeutic agents previously limited by suboptimal therapeutic performance by either improving efficacy as monotherapy or reducing side effects. Such methods and compositions are particularly applicable to bisantrene or derivatives, analogs, or prodrugs thereof.

Combinatorial methods to improve the therapeutic benefit of bisantrene and analogs and derivatives thereof

The present invention describes methods and compositions for improving the therapeutic efficacy of therapeutic agents previously limited by suboptimal therapeutic performance by either improving efficacy as monotherapy or reducing side effects. Such methods and compositions are particularly applicable to bisantrene or derivatives, analogs, or prodrugs thereof. Such methods and compositions are particularly useful for treatment of malignancies.

Compositions to improve the therapeutic benefit of bisantrene and analogs and derivatives thereof

Methods and compositions suitable for the treatment of malignancies such as recurrent glioma and progressive secondary brain tumor are disclosed. These methods employ a hexitol derivative such as dianhydrogalactitol, a derivative or analog of dianhydrogalactitol, diacetyldianhydrogalactitol, or a derivative or analog of diacetyldianhydrogalactitol. The compositions can include such hexitol derivatives.

Use of dianhydrogalactitol and analogs and derivatives thereof to treat recurrent malignant glioma or progressive secondary brain tumor

The present invention is directed to methods for treatment of malignancies in companion animals employing dianhydrogalactitol, diacetyldianhydrogalactitol, and dibromodulcitol, as well as analogs and derivatives thereof, in addition to a method to improve the efficacy and/or reduce the side effects of the administration of a therapeutic agent selected from the group consisting of dianhydrogalactitol, a derivative of dianhydrogalactitol, diacetyldianhydrogalactitol, a derivative of diacetyldianhydrogalactitol, dibromodulcitol, and a derivative of dibromodulcitol to a veterinary subject, the method comprising the steps of: (1 (identifying at least one factor or parameter associated with the efficacy and/or occurrence of side effects of the administration of the therapeutic agent to the veterinary subject; and (2) modifying the factor or parameter to improve the efficacy and/or reduce the side effects of the administration of the therapeutic agent to the veterinary subject.

Veterinary use of dianhydrogalactitol, diacetyldianhydrogalactitol, and dibromodulcitol to treat malignancies

An adapter/converter circuit converts transmissions by a mobile telephone built for one standard (e.g., PCS) from the telephone transmit/base station receive frequency of that one standard to the telephone transmit/base station receive frequency of another standard (e.g., cellular), and converts transmissions by a base station or similar device (e.g., a base station simulator) from the telephone receive/base station transmit frequency of the one standard to the telephone receive/base station transmit frequency of the other standard. The two frequency conversions occur simultaneously on two parallel legs under the control of a PLL dual frequency synthesizer, which is in turn controlled by user input (in the case where the adapter is used to allow, e.g., PCS telephones to be tested on cellular test equipment) or by the base station (in the case where the adapter is used to allow, e.g., PCS telephones to be used with a cellular base station).

Mobile telephony standards converter

An amplifier with negative feedback, disposed in an integrated circuit arrangement, comprises an input amplification stage, configured to receive an input signal. A feedback stage configured to receive the output signal provided by the amplification stage, and provide a corresponding feedback signal to the amplification stage. A driver stage, coupled to the input stage, configured to receive the output signal provided by the amplification stage, and provide the output signal of the amplifier.

Low voltage variable gain amplifier with feedback

A transceiver operable in both the cellular and PCS frequency bands which uses a single voltage controlled local oscillator in an intermediate frequency stage for both the cellular and PCS signals. The oscillator is operative for upconverting transmitter signals and downconverting receive signals for both cellular operation and PCS operation. A second voltage controlled local oscillator in a stage between the transceiver antenna and the intermediate frequency stage is operative for only PCS operation to upconvert PCS transmitter signals and to downconvert PCS receive signals. This is accomplished by the use of a switchable intermediate frequency local oscillator in the transmitter path of both the cellular and PCS signals.

Dual band cellular/PCS transceiver

A fixed dual frequency band antenna for a dual frequency band radio transceiver where the two frequency bands are not harmonically related. The antenna includes a straight radiating antenna portion terminated by a helical wire radiating antenna portion, with the total electrical length of the antenna being approximately three quarters of the wavelength at the center frequency of the higher of the two frequency bands. A conductive radiating cap terminates the helical portion and a conductive antenna base is connected to the straight portion at the end opposite the helical portion. A matching circuit coupled between the base and the transceiver circuitry is arranged to substantially cancel the reactive portion of the impedance of the antenna for both frequency bands and to substantially equalize the resistive portion of the impedance of the antenna to the resistive portion of the output impedance of the radio transceiver. The length of the antenna is such that, together with the matching circuit, the resistive portion of the impedance of the antenna is substantially the same for both frequency bands.

Fixed dual frequency band antenna

In one embodiment the present invention includes an arrangement for monitoring RF signals for use in a base station, said arrangement comprising a demodulation circuit operable to demodulate RF signals, an RF signal transceiver, and a controller. The RF signal transceiver is operable to transmit downlink RF signals to a wireless terminal and receive uplink RF signals from the wireless terminal. The RF transceiver further comprises: an antenna operable to receive first RF signals within a first frequency band and second RF signals within a second frequency band; a signal router connected to the antenna and having first and second ports, said signal router operable to provide signals within the first frequency band to the first port and signals within the second frequency band to the second port; a first RF switch connected to the first port; a first RF signal path connected to the first RF switch; a second RF signal path connected to the second port, and a second RF switch connected to the first RF signal path and the second RF signal path, said second RF switch having an output for connection to the demodulation circuit. The controller is operably connected to the first RF switch, the second RF switch, and the demodulation circuit. The controller causes the first RF switch to connect the first signal path to the first signal port and further causes the second RF switch to connect the first RF signal path to the demodulation circuit to facilitate monitoring of the first RF signals, and wherein the controller causes the second RF switch to connect the second signal path to the demodulation circuit to facilitate monitoring of the second RF signals.

Channel usage monitoring arrangement for base station

Growing community of inventors

Yardley, PA, United States of America

William J Garner