The United States of America, as Represented by the Secretary, Department of Health and Human Services

The United States of America as Represented by the Department of Health

William J Bellini

Larry J Anderson

Thomas G Ksiazek

Anthony Sanchez

Pierre E Rollin

Cara Carthel Burns

M Steven Oberste

Raymond Campagnoli

William Allan Nix

Paul A Rota

Dean D Erdman

Mark A Pallansch

James A Comer

Suxiang Tong

Cynthia Goldsmith

Stephan S Monroe

Shannon L Emery

Charles D Humphrey

Joseph P Icenogle

Teresa C T Peret

Sherif R Zaki

Qi Chen

Jeanette Guarner

Richard F Meyer

Christopher D Paddock

Michael D Bowen

Wun-Ju Shieh

Jennifer S Rota

Byron T Cook

Disclosed herein is a newly isolated human coronavirus (SARS-CoV), the causative agent of severe acute respiratory syndrome (SARS). Also provided are the nucleic acid sequence of the SARS-CoV genome and the amino acid sequences of the SARS-CoV open reading frames, as well as methods of using these molecules to detect a SARS-CoV and detect infections therewith. Immune stimulatory compositions are also provided, along with methods of their use.

Coronavirus isolated from humans

The present invention provides nucleic acids encoding consensus hemagglutinin and consensus fusion polypeptides which contain at least one amino acid substitution relative to the Moraten vaccine strain that is found in at least one strain of wild-type measles virus. Nucleic acid reagents useful for detecting and differentiating wild-type measles strains by polymerase chain reaction and a method utilizing the same are provided. Recombinant vectors comprising nucleic acids encoding the consensus hemagglutinin and/or the consensus fusion polypeptides are also provided.

Nucleic acids encoding wild-type measles virus consensus hemagglutinin

Growing community of inventors

Lilburn, GA, United States of America

William J Bellini