Mylan Pharmaceuticals Inc.

Zeneca Limited

William J Addicks

Daniel A Snider

Kerry R Benson

Joseph P Duda

Robert Joseph Timko

Bhavnish Vinod Parikh

A pharmaceutical composition is provided containing an admixture of phenytoin sodium and an erodible matrix which extends the release of the phenytoin sodium over about a two hour period. The erodible matrix comprises binder(s) and diluent(s) which control the release of drug from the pharmaceutical composition. The erodible matrix can further comprise an alkaline pH modifier.

Phenytoin sodium pharmaceutical compositions

The invention relates to sustained release formulations comprising 11-�4-�2-(2-hydroxyethoxy)ethyl!-1-piperazinyl!dibenzo�b,f! �1,4!thiazepine or a pharmaceutically acceptable salt thereof, to methods of treating psychotic states and hyperactivity utilizing the sustained release formulations and to a process for preparing the sustained release formulations.

Pharmaceutical compositions using thiazepine

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Morgantown, WV, United States of America

William J Addicks