University of Strathclyde

Strategic Diagnostics Inc.

Ilc Therapeutics, Ltd

Alfacyte Ltd

Phyto Corporation Limited

William Howard Stimson

Alexander Irvine Gray

Chaman Lal Anand

Pauline Weatherby

Peter George Waterman

Solomon Habtemariam

Solomon Habtemarium

Peilin Zhou

Dracos Vassalos

Atilla Incecik

Christopher Mckenzie

The present invention relates to compositions and methods for promoting the induction of a cell-mediated immune response (such as that mediated by Th1 cells) and the suppression of a humoral or allergic immune response (such as that mediated by Th2 and Th17 cells). In particular, the invention relates to compositions and methods for preventing or treating allergy, such as food allergy, and associated allergic diseases, and conditions where an exaggerated Th17 response plays a detrimental role, such as inflammatory responses and autoimmune diseases. The invention further extends to the use of the compositions of the invention in the treatment and/or prophylaxis of allergy and associated allergic diseases and also of cancer.

Compositions and methods relating to the treatment of diseases

The present invention relates to compositions and methods for promoting the induction of a cell-mediated immune response (such as that mediated by Th1 cells) and the suppression of a humoral or allergic immune response (such as that mediated by Th2 and Th17 cells). In particular, the invention relates to compositions and methods for preventing or treating allergy, such as food allergy, and associated allergic diseases, and conditions where an exaggerated Th17 response plays a detrimental role. The invention further extends to the use of the compositions of the invention in the treatment and/or prophylaxis of allergy and associated allergic diseases and also of cancer.

A method is provided for the treatment and/or prophylaxis of a condition where an enhancement of a Th1-mediated immune response and suppression of a Th2/Th17-mediated immune response are desired. The method comprises the step of administering to a subject in need thereof a therapeutically effective amount of at least one interferon alpha subtype selected from IFN-&#x3b1;10, IFN-&#x3b1;14, and a hybrid thereof. The condition to be treated may be selected from the group consisting of an autoimmune disease, an inflammatory disease (e.g. inflammatory bowel disease) and allergy or an associated allergic condition.

Compositions and methods relating to the treatment of diseases involving TH1 and TH2/TH17

A composition for treating waters, e.g. ballast water or injection water for oil recovery, to kill in-situ aquatic invasive species comprises at least one biocide capable of killing both animal and plant micro-organisms. The at least one biocide preferably comprises Brilliant Green, Gentian Violet, and/or erythrosine, and a wetting agent or detergent-like compound such as CTAB or CTAC. The invention also relates to a system for treating ballast water in situ comprising means for injecting a composition for treating ballast water; means for measuring the flow rate or amount of ballast water to be treated; means for controlling the dosing of the composition; and means for storing or receiving the composition. The invention also relates to a method of detecting viable aquatic organisms in ballast water in situ comprising detecting metabolism in viable micro-organisms in ballast water and, therefore, measuring the efficacy of any treatment.

Ballast water treatment system

A method for determining the presence and/or concentration of a water treatment polymer in an aqueous sample, comprising producing a polyclonal or monoclonal antibody to the water treatment polymer;, and using the antibody so produced as a reagent in an immunoassay, conducted on the aqueous sample.

Method for determination of water treatment polymers

A method for determining the presence and/or concentration of a water treatment polymer in an aqueous sample, comprising producing a polyclonal or monoclonal antibody to the water treatment polymer, and using the antibody so produced as a reagent in an immunoassay, conducted on the aqueous sample.

Antibody compositions for the detection and quantification of water treatment polymers

The invention provides compositions comprising uscharin and the use of uscharin to combat cell proliferation for example in the treatment of cancer. Administration of uscharin may kill or reduce the growth rate of cancer cells and may also be of application in other medical conditions presenting symptoms of excessive or uncontrolled cell proliferation. The composition may be administered by any convenient route and formulated accordingly. The composition may be administered locally or generally and may be suitably dissolved and/or suspended in a pharmaceutically acceptable liquid carrier medium.

Pharmaceutical composition containing uscharidin or its analogues

Use of stereoisomeric glycosidic compounds of formula (I) as pharmaceutical agents against psoriasis, compounds therefor and pharmaceutical formulations thereof wherein R,and R,are independently selected from &mdash;H, &mdash;OH, (1) and (2) and related esters and ethers thereto; R,is selected from &mdash;H, (3), (4), (5), (6), (7) and (8) and related esters and ethers thereto; R,is (9); R,is selected from the group &mdash;CH,, &mdash;CHO, &mdash;COOH, &mdash;CH,OH and related esters and ethers thereto; R,is selected from &mdash;OH, (10), (11), (12), (13) and (14) in the preparation of a medicament for the treatment of disease involving hyperproliferation of dermis cells.

Use of stereoisomers of calendula gylcosides for the treatment of psoriasis

A method and compound for the treatment of disease involving hyperproliferation of dermis cells is provided. In particular, compounds isolated from the species of plants known as calendula have been found to be beneficial in the treatment of psoriasis. An extract of plant material obtained from,has been found to be advantageous as an active compound in medicaments for use in the treatment of psoriasis.

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Glasgow, United Kingdom

William Howard Stimson