Leland Stanford Junior University

The United States Government As Represented by the Department of Veterans Affairs

Free-flow Packaging International, Inc.

The Brigham and Women's Hospital, Inc.

Dana-farber-cancer Institute Inc.

Atreca, Inc.

University of Colorado

William H Robinson

Lawrence Steinman

Jeremy Sokolove

Shalina Sheryl Ousman

Andrew Perkins

Oliver M Reyes

Qian Wang

Hideki Garren

Pedro Jose Ruiz

Paul J Utz

Yann Chong Tan

David A Hafler

Kai W Wucherpfennig

Wayne Volkmuth

David L Hirschberg

Shaun M Lippow

Daniel Eric Emerling

Jeff DeFalco

Paulo Fontoura

Peggy Pui-Kay Ho

Tito Serafini

Nikhil Vad

Kevin C O'Connor

Alexander Scholz

Amy Manning-Bog

Fengling Liu

Vera Huang

Norman Michael Greenberg

Jessica Finn

Katherine McLaughlin

Jennifer L Kanter

Xiaoyan Zhao

Jeff Defalco

Michael Holers

Provided herein are antibodies that bind to tumor tissue through a binding interaction with an extracellular RNA-protein complex. Such antibodies are used in methods of inducing an immune response and methods of inhibiting tumor cell growth. Additionally provided are methods of producing such antibodies.

Antibodies that bind tumor tissue for diagnosis and therapy

Disclosed herein are compositions and methods for sequencing, analyzing, and utilizing samples such as single samples. Also disclosed herein are compositions and methods for matching together two or more sequences from a sample. Also disclosed herein are compositions and methods for expressing and screening molecules of interest.

Identification of polynucleotides associated with a sample

Compositions and methods are provided for inhibiting or treating the early and established stages of inflammatory diseases by administration of an effective dose of the desethylhydroxychloroquine (DHCQ). A benefit of the methods is the ability to deliver a dose of agent that is effective in treating inflammation while sparing the individual from retinal toxicity.

Desethylhydroxychloroquine for the treatment of diseases associated with inflammation

Compositions and methods are provided for prognostic classification of rheumatoid arthritis disease patients into subtypes, which subtypes are informative of the patient's need for therapy and responsiveness to a therapy of interest.

Fibrinogen immune complexes to diagnose and guide therapy in rheumatoid arthritis

The invention provides methods for treating inflammatory diseases by administering to the subject an effective amount of an agent that provides alpha B-crystallin activity, where the dose is effective to suppress or prevent initiation, progression, or relapses of disease, including the progression of established disease. In some embodiments, the methods of the invention comprise administering to a subject having a pre-existing inflammatory disease condition, an effective amount of alpha B-crystallin protein, to suppress or prevent relapses of the disease.

Alpha B-crystallin as a therapy for multiple sclerosis

Alpha B-crystallin as a therapy for ischemia or inflammation

To perform large-scale multiplex analysis of lipid-specific binding, lipid microarrays were developed. Lipids identified as disease associated, or analogs there, can be tolerogenic to patients suffering from autoimmune disease. Lipid array analysis has revealed anti-lipid antibodies in patients with immune disorders, and may contribute to the pathogenesis of disease.

Method of treating multiple sclerosis with phosphocholine containing lipids

Methods and compositions for diagnosing and treating autoimmune disease, e.g., acute disseminated encephalomyelitis (ADEM), are described.

Diagnosis of autoimmune disease

Alpha B-crystallin as a therapy for rheumatoid arthritis

This invention provides a method for determining the antibody specificity profile in an individual. This specificity profile reveals the individual's immune response to multiple antigens and/or epitopes of autoantigens, allergens, graft antigens, etc. The antibody specificity profile is determined through the binding of patient samples comprising antibodies to the arrays. The array can comprises antigens and epitopes. The invention also provides the means and methods for determining antigen or epitope specificity profiles that can be used in the development of either generic and individualized diagnosis and treatment for immune related diseases, including autoimmune disease, allergy and graft rejection.

Therapeutic and diagnostic uses of antibody specificity profiles

This invention provides a method of treating or preventing a disease in an animal associated with one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present or involved in a non-physiologic process in the animal comprising administering to the animal a self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) associated with the disease. Administration of the self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) modulates an immune response to the self-protein(s), -polypeptide(s) or -peptide(s) expressed from administration of the self-vector. The invention also provides a composition comprising a polynucleotide encoding one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present non-physiologically in a treated animal useful in treating or preventing a disease associated with the self-protein(s), -polypeptide(s), or -peptide(s) present in and/or the target of a non-physiologic process in the animal.

Polynucleotide therapy

Machine for inflating and sealing a preconfigured cushioning material which is wound in a roll on a hollow cylindrical core and has superposed layers of plastic film sealed together to form rows of interconnected, inflatable cells, a longitudinally extending channel near one edge of the material and inlet passageways interconnecting the channel and the rows of cells. The machine includes a rotatively mounted roll support shaft, a hub mounted on the shaft for engagement with the core at the end of the roll near the channel, a circumferentially expandable roll gripper for locking engagement with the inner wall of the cylindrical core, a feed mechanism for drawing the material and feeding it along a predetermined path, an inflator for injecting air into the cells, a nip roller, a pressing mechanism for pressing the nip roller against the roll of material, and a sealing mechanism for sealing the inlet passageways to retain the air in the cells.

Machine for inflating and sealing air filled cushioning materials

Machine for inflating and sealing a preconfigured cushioning material which includes a rotatively mounted roll support shaft having a fixed end and a free end, a hub mounted on the shaft near the fixed end for engagement with a cylindrical core at the end of a roll of film material, a circumferentially expandable roll gripper at the free end of the shaft for locking engagement with the inner wall of the core, an inflator having a conically tapered tip and a plurality of outlet openings for injecting air into cells of the film material, a nip roller pressing against the roll of film material to limit the flow of air into the cells of the film material on the roll, and sealer for sealing the inlet passageways to retain the air in the cells.

Machine for inflating and sealing air-filled cushioning materials

Growing community of inventors

Palo Alto, CA, United States of America

William H Robinson