Research, Incorporated

Yale University

William H Prusoff

Tai-Shun Lin

Paul H Fischer

George T Shiau

This invention relates to the use of 2',3'-dideoxycytidin-2'-ene (2',3'-dideoxy-2',3'-didehydrocytidine) in treating patients infected with a retrovirus.

Use of 2',3'-dideoxycytidin-2'-ene (2'-

This disclosure describes the preparation of 3'-amino-2', 3'-dideoxyctidine and the pharmacologically acceptable salts thereof which are useful in inhibiting the growth of transplanted tumors in mammals.

Intermediates in the preparation of 3'-amino-2',3'-dideoxycytidine and

This invention relates to the use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with a retrovirus.

Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in

This invention relates to 3'-azido-2',3'-dideoxy-5-halouridine, particularly, 3'-azido-2', 3'-dideoxy-5-bromouridine and 3'-azido-2',3'-dideoxy-5-iodouridine, and its use in treating patients infected with a retrovirus.

3'-azido-2',3'-dideoxy-5-halouridine and its use in treating patients

This disclosure describes the preparation of 3'-amino-2',3'-dideoxycytidine and the pharmacologically acceptable salts thereof which are useful in inhibiting the growth of transplanted tumors in mammals.

3'-amino-2',3'-dideoxycytidine and the pharmacologically acceptable

This disclosure describes the preparation of therapeutically effective compositions of matter containing a nucleoside such as thymidine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) which are useful in inhibiting the growth of transplanted tumors in mammals.

Compositions and method for alleviating the toxic effects of

Alkyl and haloalkyl nitrosourea analogs of thymidine are useful in the treatment of cancers in mice.

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North Branford, CT, United States of America

William H Prusoff