University of Michigan

Berry and Associates, Inc.

Other

William H Pearson

Erik J Hembre

John C Hodges

David A Berry

Yam Foo Poon

Yi Ren

Tanya M Barber

Jeffrey Tulin-Silver

The present invention provides for reagents for the introduction of colorimetric-oxycarbonyl protecting groups, compounds bearing colorimetric-oxycarbonyl protecting groups, and the use thereof in solid-supported organic syntheses of oligonucleotides, polypeptides, polysaccharides, and combinatorial libraries.

Colorimetric-oxycarbonyl protecting groups for use in organic syntheses

The specification discloses quenchers of excited state energy, probes and other conjugates comprising the same, and methods for their use. The quenchers of excited state energy have a structure comprising at least one reactive functional group for linking the quencher to a carrier molecule and at least three radicals covalently linked via exocyclic diazo bonds, the at least three radicals including at least one comprising a julolidine of the nominal formula: and the remainder of the at least three radicals being selected from the group of substituted and unsubstituted aryls, substituted and unsubstituted heteroaryls, and combinations thereof.

Dark quenchers, probes and other conjugates incorporating the same, and their use

This invention relates to 6 or 7 substituted swainsonine analogues, processes for their preparation and use as therapeutic agents. The invention also relates to pharmaceutical compositions containing the compounds and their use as therapeutics.

6-and 7-substituted analogs of swainsonine their preparation and therapeutic use

Swainsonine derivatives and methods for preparing the same

(-)-Swainsonine may be prepared by (i) reacting a compound of formula (8): ##STR1## wherein OMs is methanesulfonyl with H.sub.2 in the presence of Pd(OH).sub.2 followed by NaOMe, to obtain a compound of formula (9): ##STR2## and (ii) reducing the carbonyl group and hydrolyzing the ketal group in the compound of formula (9) to obtain (-)-swainsonine of formula (1): ##STR3##

Method for preparing swainsonine

A stable, non-irritating composition and method for treating, without side effects, acute or chronic rhinosinusitis and its associated upper airway symptoms. The composition and treatment are useful for relieving the symptoms, and shortening the duration, of acute or chronic rhinosinusitis. The composition comprises a therapeutically effective solution having a pH of about 6.0, of ascorbic acid and caffeine, in combination with other soluble vitamins, natural ingredients and preservatives in a pharmaceutically acceptable carrier. The method includes the steps of preparing and administering the composition to the nasal membranes of a patient in the form of a nasal spray or drops.

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Ann Arbor, MI, United States of America

William H Pearson