Medtronic Minimed, Inc.

Tensys Medical, Inc.

Glumetrics, Inc.

William H Markle

Russell D Hempstead

David R Markle

Stuart L Gallant

Gregory I Voss

Mark W Perona

Manouchehr Goharlaee

Simon E Finburgh

Ronald S Conero

Ronald J Vidischak

Stephen R Hessel

An improved method and apparatus for non-invasively assessing one or more hemodynamic parameters associated with the circulatory system of a living organism. In one aspect, the invention comprises a method of measuring a hemodynamic parameter (e.g., arterial blood pressure) by applanating or compressing portions of tissue proximate to the blood vessel of concern until a desired condition is achieved, and then measuring the hemodynamic parameter. Such applanation effectively mitigates transfer and other losses created by the tissue proximate to the blood vessel, thereby facilitating accurate and robust tonometric measurement. An algorithm adapted to maintain optimal levels of applanation is also described. Methods and apparatus for scaling such hemodynamic parameter measurements based on subject physiology, and providing treatment to the subject based on the measured parameters, are also disclosed.

Method and apparatus for non-invasively measuring hemodynamic parameters using parametrics

Disclosed are embodiments that relate to the deployment of a glucose sensor comprising an optical fiber into a physiological fluid, wherein the optical fiber has disposed along a distal region thereof a chemical indicator system comprising a fluorophore and a glucose binding moiety immobilized within a hydrogel, wherein the components of the chemical indicator system are in a dry state before deployment. Also disclosed is a one-point in vivo calibration of the chemical indicator system based on an independently measured glucose concentration.

Dry insertion and one-point in vivo calibration of an optical analyte sensor

Embodiments of the present invention relates to analyte sensors. In particular, the preferred embodiments of the present invention relate to non-consuming intravascular glucose sensors based on fluorescence chemistry.

Equilibrium non-consuming fluorescence sensor for real time intravascular glucose measurement

A method for monitoring blood glucose concentration in a patient in need thereof is disclosed. The method comprises deploying an equilibrium glucose sensor within interstitial fluid in the patient in need and coupling the equilibrium glucose sensor to a monitor configured to detect a signal and configured to display the blood glucose concentration.

Use of an equilibrium sensor to monitor glucose concentration

A method for achieving tight glycemic control in a patient in need thereof is disclosed. The method comprises deploying an equilibrium glucose sensor within a blood vessel in the patient, coupling the sensor to a monitor that displays the blood glucose concentration, and administering a blood glucose regulator when the blood glucose concentration varies outside of the predetermined concentration range. The blood glucose regulator is administered in an amount sufficient to return the blood glucose concentration to within the predetermined concentration range, thereby achieving tight glycemic control.

Use of an equilibrium intravascular sensor to achieve tight glycemic control

The present invention relates to a sensor for percutaneous insertion and intravascular residence without an indwelling cannula. In preferred embodiments, a glucose sensor is inserted into a blood vessel using a removable cannula. After the cannula is removed, the glucose sensor remains within the blood vessel by itself and forms a seal with the patient's tissue.

Sensor for percutaneous intravascular deployment without an indwelling cannula

An improved method and apparatus for monitoring a plurality of physiologic parameters associated with a living subject. In one aspect, the invention comprises a monitoring apparatus capable of non-invasively and continuously monitoring the blood pressure, heart rate (ECG), and weight of the subject. The apparatus further includes a display, input device, and one or more communications links such that data and other information may be communicated between the apparatus and one or more remote locations. In one exemplary embodiment, the apparatus comprises a portable monitoring station disposed in the subject's home, which is kept in communication with a remote medical facility via a wireless interface and PSTN or data network. Two-way communications of monitored data, video, audio, and other types of information is provided to facilitate remote care of the subject, and obviate the need for an in-home caregiver or frequent trips to the medical facility. A communications system for exchanging data between the various locations, and computer program allowing such data exchange, are also disclosed.

Growing community of inventors

Laguna Niguel, CA, United States of America

William H Markle