University of California

Massachusetts Institute of Technology

William H Grover

Richard A Mathies

Scott R Manalis

Thomas P Burg

Chung N Liu

Philip Dextras

Sungmin Son

Yao-Chung Weng

Andrea Kristine Bryan

Eric Lagally

Alison Skelley

Erik C Jensen

Michel Godin

Shirin Mesbah Oskui

Brittney A McKenzie

A method for of validating the identity of one of more component(s) in a substance including: obtaining a substance; placing the substance in a plenum with a sealed bottom; exposing the substance to a perturbation; digitally recoding the time-dependent changes in the substance after exposing the substance to the perturbation; producing a chronological fingerprint of the changes, where the chronological fingerprint is a digital multi-dimensional image of the changes as a function of time; and comparing the chronological fingerprint to chronological fingerprints for known substances to validate the one or more component(s) in the substance being measured. Also described are associated systems and computer program products for implementing the method.

Method for characterizing and identifying substances

A method of reducing the toxicity of a 3D-printed part is provided. The method includes exposing the part to ultraviolet light sufficient to reduce the toxicity of the part. The toxicity of the ultraviolet light-treated part can be based on a comparison with the toxicity of a similarly prepared part not exposed to ultraviolet light.

Treatment for reducing the toxicity of 3D-printed parts

Methods and apparatus for implementing microfluidic analysis devices are provided. A monolithic elastomer membrane associated with an integrated pneumatic manifold allows the placement and actuation of a variety of fluid control structures, such as structures for pumping, isolating, mixing, routing, merging, splitting, preparing, and storing volumes of fluid. The fluid control structures can be used to implement a variety of sample introduction, preparation, processing, and storage techniques.

Fluid control structures in microfluidic devices

Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Suspended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods. Methods include techniques to provide differential measurements by varying the fluid density for repeated measurements on the same particle or cell.

Method and apparatus for trapping single particles in microfluidic channels

Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Suspended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods and for changing the fluid properties within the SMR during the extended periods. Methods include techniques to provide for cell growth over time and over time in response to changing fluid properties to aid in determining parameters such as drug resistance and drug susceptibility.

Method and apparatus for extended time and varying environment measurements of single particles in microfluidic channels

Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Susppended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods. Methods include techniques to provide differential measurements by varying the fluid density for repeated measurements on the same particle or cell.

Membrane valves and latching valve structures for microfluidic devices are provided. A demultiplexer can be used to address the latching valve structures. The membrane valves and latching valve structures may be used to form pneumatic logic circuits, including processors.

Growing community of inventors

Medford, MA, United States of America

William H Grover