Other

Verenium Corporation

Knukonceptz.com, Ltd.

California Institute of Technology

The Scripps Research Institute

Irm LLC

William H Greenberg

Mark Joseph Burk

Kelvin Wong

Alexander Varvak

Danny Finley

Chi-Huey Wong

Frances H Arnold

Toby Howard Richardson

David Paul Weiner

Grace DeSantis

Michael D Levin

Tim S Hitchman

Lishan Zhao

Robert Epple

Jennifer Ann Chaplin

Zuolin Zhu

Aileen Milan

Brian R Morgan

Sarah R Hanson

Jared C Lewis

Sabine Bastian

Karen Kustedjo

Clay Bennett

Patti Kretz

Zilin Huang

Romas Kudirka

Yuuichi Mitsuda

Michael M Chen

Battery terminal

A fuse and power distribution block is provided which includes a polymer base, and multiple conductive base blocks for connection with incoming power lines or outgoing accessory lines. Each conductive base block also provides multiple alternative fuse connections on a first upper horizontal platform, a second lower horizontal platform, and a third intermediate vertical platform interconnecting the first and second platforms. The fuse and power distribution block may, depending on the desired accessory system, include 4 or 6 conductive base blocks. The fuse and power distribution block has an attractive transparent polymer cover and shell.

Fuse and power distribution block

A jewelry clasp includes a first clasp housing piece, and a second clasp housing piece. The first and second clasp housing pieces each have an internal support surface and respective interface surfaces that are constructed and arranged to provide a mating fit between the first and second clasp housing pieces. A first magnetic attraction member is disposed at the internal support surface of the first clasp housing piece and a second magnetic attraction member is disposed at the internal support surface of the second clasp housing piece. The interface surfaces are separately disposed inclined plane surfaces including at least a first inclined surface that is inclined in a direction longitudinal of the clasp, and at least a second inclined surface that is a directed in a direction transverse to the longitudinal axis of the clasp.

Jewelry clasp

The disclosure relates to engineered P450 polypeptides and use of such polypeptides in chemoenzymatic methods to construct selectively protected carbohydrates, which are useful as building blocks for preparation of carbohydrate derivatives and oligosaccharides

Methods and compositions for preparation of selectively protected carbohydrates

The invention provides aldolases, nucleic acids encoding them and methods for making and using them, including chemoenzymatic processes for making &#x3b2;,&#x3b4;-dihydroxyheptanoic acid side chains and compositions comprising these side chains, e.g., [R&#x2014;(R*,R*)]-2-(4-fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-(phenylamino)-carbonyl]-1H-pyrrole-1-heptanoic acid (atorvastatin, LIPITOR&#x2122;), rosuvastatin (CRESTOR&#x2122;), fluvastatin (LESCOL&#x2122;), related compounds and their intermediates.

Chemoenzymatic methods for the synthesis of statins and statin intermediates

The invention provides biocatalytic methods for the manufacture of pure single enantiomer compounds. This invention provides methods of screening for enzymes which are highly enantioselective or enzymes that can provide any desired stereoisomer of a compound. The invention provides the use of single enantiomer substrates in performing a growth screen of a clonal library to identify highly stereoselective enzymes. In one aspect, methods for screening and identification of enzymes, e.g., transaminases, nitrilases, aldolases, epoxide hydrolases are provided. Methods for the production and screening of gene libraries generated from nucleic acids isolated from more than one organism for enzyme, e.g., transaminase, activities are also provided.

Methods for the manufacture of pure single enantiomer compounds and for selecting enantioselective enzymes

The invention provides synthetic chemical and chemoenzymatic methods of producing simvastatin and various intermediates. In one aspect, enzymes such as hydrolases, e.g., esterases, are used in the methods of the invention. 

Methods for making simvastatin and intermediates

The invention provides novel aldolases, nucleic acids encoding them and methods for making and using them, including chemoenzymatic processes for making &#x3b2;,&#x3b4;-dihydroxyheptanoic acid side chains and compositions comprising these side chains, e.g., [R-(R*,R*)]-2-(4-fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-(phenylamino)-carbonyl]-1H-pyrrole-1-heptanoic acid (atorvastatin, LIPITOR&#x2122;), rosuvastatin (CRESTOR&#x2122;), fluvastatin (LESCOL&#x2122;), related compounds and their intermediates.

Aldolases, nucleic acids encoding them and methods for making and using them

The present invention provides combinatorial libraries of nucleoside analog compounds and methods of making the libraries. In addition, the present invention provides methods of assaying the libraries for agonists or antagonists of a broad array of targets of therapeutic importance.

Nucleoside analog libraries

A jewelry clutch includes a body portion having an open cavity formed therein and an elastomeric clutch element in the cavity for receiving and securing a post of a jewelry item in the clutch. The body portion has a substantially triangular transverse cross sectional configuration to enable the clutch to be more easily grasped between the thumb and first two fingers of a hand of a user.

Jewelry clutch

A chassis and suspension system includes a chassis which is pivotally suspended from front and rear subchassis, and front and rear interchassis springs which resiliently restrict the pivotal movement of the chassis relative to the front and rear subchassis, respectively. Front and rear wheel connecting assemblies mount front and rear wheels, respectively, on the front and rear subchassis, respectively, so that they are independently resiliently upwardly movable in substantially parallel relation to the central vertical axes of the respective subchassis. By properly dimensioning the components of the chassis and suspension system, it functions so that during cornering, only the chassis rotates while the front and rear subchassis remain in substantially unrotated dispositions, whereby the wheels remain substantially perpendicular to a roadway surface therebeneath to maximize tire adhesion.

Chassis and suspension system for vehicles

Growing community of inventors

Lincoln, RI, United States of America

William H Greenberg